Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loperamide
Drug ID BADD_D02428
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status approved
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D08144
MeSH ID D008139
PubChem ID 3955
TTD Drug ID D0CS2F
NDC Product Code Not Available
UNII 6X9OC3H4II
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H33ClN2O2
CAS Registry Number 53179-11-6
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Brain oedema17.07.02.003; 12.01.10.0100.000676%
General physical health deterioration08.01.03.018--Not Available
Ventricular hypokinesia02.04.02.0130.000338%Not Available
Haemodynamic instability24.03.02.0060.000507%Not Available
Musculoskeletal stiffness15.03.05.027--Not Available
Haemorrhage24.07.01.002--Not Available
Faecaloma07.01.03.0040.000338%Not Available
Colitis microscopic07.08.01.011--Not Available
Pulseless electrical activity02.03.04.0200.000338%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Adverse event08.06.01.0100.000913%Not Available
Cardiac disorder02.11.01.0030.000338%Not Available
Gastrointestinal motility disorder07.02.03.001--Not Available
Therapeutic reaction time decreased08.06.01.015--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Cytopenia01.03.03.0120.000507%Not Available
Sphincter of Oddi dysfunction09.02.02.004; 07.18.02.0020.000338%Not Available
Treatment failure08.06.01.017--Not Available
Brain injury19.07.03.007; 17.11.01.0030.000507%Not Available
Anorectal discomfort07.03.03.003--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.004--
Acute kidney injury20.01.03.0160.000845%
Faeces soft07.01.03.008--Not Available
Anal incontinence17.05.01.021; 07.01.06.029--
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000676%Not Available
Seizure like phenomena17.12.03.0300.000338%Not Available
Arrhythmic storm02.03.04.0210.000507%Not Available
Dilated cardiomyopathy02.04.01.0170.000676%Not Available
Drug use disorder19.07.06.0120.001690%Not Available
Illness08.01.03.091--Not Available
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