Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexmethylphenidate
Drug ID BADD_D02457
Description Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181].
Indications and Usage Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment[A177187,Label].
Marketing Status approved; investigational
ATC Code N06BA11
DrugBank ID DB06701
KEGG ID D07806
MeSH ID D064699
PubChem ID 154101
TTD Drug ID D02QCD
NDC Product Code Not Available
UNII M32RH9MFGP
Synonyms Dexmethylphenidate Hydrochloride | Hydrochloride, Dexmethylphenidate | Focalin XR | XR, Focalin | Dexmethylphenidate | Focalin
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 40431-64-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Euphoric mood19.04.02.0060.000580%
Feeling abnormal08.01.09.0140.001824%Not Available
Feeling jittery08.01.09.0160.001244%Not Available
Formication19.10.04.002; 17.02.06.0180.000375%Not Available
Gastrointestinal disorder07.11.01.0010.000375%Not Available
Hallucination19.10.04.0030.000256%
Hallucinations, mixed19.10.04.0080.000170%Not Available
Headache17.14.01.0010.003614%
Hypersensitivity10.01.03.0030.001159%
Insomnia19.02.01.002; 17.15.03.0020.002318%
Irritability19.04.02.013; 08.01.03.0110.001415%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000545%
Malaise08.01.01.0030.001790%
Mood altered19.04.02.0070.000835%Not Available
Mood swings19.04.03.0010.001125%Not Available
Movement disorder17.01.02.0100.000375%Not Available
Muscle twitching15.05.03.0050.000580%Not Available
Palpitations02.11.04.0120.002403%
Paranoia19.05.01.0050.000545%Not Available
Peripheral coldness23.06.04.008; 24.04.03.006; 08.01.09.0100.000375%Not Available
Pollakiuria20.02.02.0070.000580%
Psychomotor hyperactivity17.01.02.011; 19.11.02.0030.001705%Not Available
Restlessness19.11.02.002; 17.02.05.0210.000750%
Seizure17.12.03.0010.000341%
Sleep disorder19.02.04.0010.000580%Not Available
Somnolence19.02.05.003; 17.02.04.0060.000665%
Speech disorder17.02.08.003; 22.12.03.027; 19.19.02.0020.000170%Not Available
Suicidal ideation19.12.01.0030.000545%
Tachycardia02.03.02.0070.000545%Not Available
Tardive dyskinesia17.01.02.0120.000170%Not Available
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