Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexmethylphenidate
Drug ID BADD_D02457
Description Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181].
Indications and Usage Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment[A177187,Label].
Marketing Status approved; investigational
ATC Code N06BA11
DrugBank ID DB06701
KEGG ID D07806
MeSH ID D064699
PubChem ID 154101
TTD Drug ID D02QCD
NDC Product Code Not Available
UNII M32RH9MFGP
Synonyms Dexmethylphenidate Hydrochloride | Hydrochloride, Dexmethylphenidate | Focalin XR | XR, Focalin | Dexmethylphenidate | Focalin
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 40431-64-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Therapeutic response unexpected08.06.01.0010.000869%Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.000256%Not Available
Tic19.11.04.001; 17.02.05.0240.001585%Not Available
Tremor17.01.06.0020.001295%
Ventricular fibrillation02.03.04.0080.000170%
Vision blurred17.17.01.010; 06.02.06.0070.000869%
Visual impairment06.02.10.0130.000750%Not Available
Energy increased08.01.03.0170.001449%Not Available
Performance status decreased08.01.03.0420.001534%Not Available
Eye movement disorder06.05.02.008; 17.02.05.0250.000375%Not Available
Abnormal behaviour19.01.01.0010.007756%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.005761%
Adverse drug reaction08.06.01.0090.000869%Not Available
Drug intolerance08.06.01.0130.001244%Not Available
Grimacing17.02.05.0290.000170%Not Available
Unevaluable event08.01.03.0510.000375%Not Available
Autism spectrum disorder17.03.05.003; 19.22.02.0020.000511%Not Available
Treatment failure08.06.01.0170.000665%Not Available
Communication disorder19.19.01.0080.000170%Not Available
Attention deficit hyperactivity disorder19.21.04.0040.001705%Not Available
Behaviour disorder19.01.01.0050.000580%Not Available
Therapeutic product effect decreased08.06.01.0500.001415%Not Available
Therapeutic product effect incomplete08.06.01.0520.000375%Not Available
Therapeutic response changed08.06.01.0590.000375%Not Available
Therapy non-responder08.06.01.0630.001449%Not Available
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