Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valbenazine
Drug ID BADD_D02491
Description Valbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Indications and Usage For the treatment of tardive dyskinesia in adults [FDA Label].
Marketing Status approved; investigational
ATC Code N07XX13
DrugBank ID DB11915
KEGG ID D10675
MeSH ID C000603978
PubChem ID 24795069
TTD Drug ID D63WMQ
NDC Product Code 47049-021; 66406-0314; 70370-2040; 70370-2048; 47049-008; 47049-009; 70370-1060; 70370-1080; 66406-0274
UNII 54K37P50KH
Synonyms valbenazine | (2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate | NBI-98854 | Ingrezza | valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
Chemical Information
Molecular Formula C24H38N2O4
CAS Registry Number 1025504-45-3
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nocturia20.02.03.0010.001184%Not Available
Oculogyric crisis17.01.03.002; 06.05.02.0020.001830%Not Available
Panic attack19.06.04.0010.003284%Not Available
Panic reaction19.06.04.0030.002100%Not Available
Paranoia19.05.01.0050.005114%Not Available
Parkinsonism17.01.05.0030.151652%Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.000808%Not Available
Pollakiuria20.02.02.0070.006676%
Psychomotor hyperactivity17.01.02.011; 19.11.02.0030.003661%Not Available
Rash23.03.13.0010.098948%Not Available
Restlessness19.11.02.002; 17.02.05.0210.035962%
Salivary hypersecretion07.06.01.0090.024064%Not Available
Sedation17.02.04.0050.106593%Not Available
Sleep paralysis19.02.02.004; 17.15.02.0050.001830%Not Available
Sluggishness08.01.01.0040.003661%Not Available
Somnambulism17.15.02.004; 19.02.03.0060.002100%Not Available
Somnolence19.02.05.003; 17.02.04.0060.293238%
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.012436%Not Available
Suicidal ideation19.12.01.0030.027617%
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.013620%Not Available
Tardive dyskinesia17.01.02.0120.195043%Not Available
Tic19.11.04.001; 17.02.05.0240.006676%Not Available
Tongue movement disturbance17.02.05.049; 07.14.02.0160.002746%Not Available
Tongue spasm07.14.02.0080.001830%Not Available
Tongue ulceration07.14.01.0030.001830%Not Available
Toothache07.09.06.0010.001830%
Torticollis17.01.03.003; 15.05.04.0030.002746%Not Available
Tremor17.01.06.0020.184330%
Trismus17.01.03.004; 15.05.04.0040.003661%
Urinary incontinence20.02.02.010; 17.05.01.0080.006676%
The 3th Page    First    Pre   3 4 5    Next   Last    Total 5 Pages