Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valbenazine
Drug ID BADD_D02491
Description Valbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Indications and Usage For the treatment of tardive dyskinesia in adults [FDA Label].
Marketing Status approved; investigational
ATC Code N07XX13
DrugBank ID DB11915
KEGG ID D10675
MeSH ID C000603978
PubChem ID 24795069
TTD Drug ID D63WMQ
NDC Product Code 47049-021; 66406-0314; 70370-2040; 70370-2048; 47049-008; 47049-009; 70370-1060; 70370-1080; 66406-0274
UNII 54K37P50KH
Synonyms valbenazine | (2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate | NBI-98854 | Ingrezza | valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
Chemical Information
Molecular Formula C24H38N2O4
CAS Registry Number 1025504-45-3
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oromandibular dystonia17.01.03.0060.001184%Not Available
Cardiovascular symptom02.11.04.002; 24.03.02.0250.001454%Not Available
Cervical spinal stenosis17.10.02.006; 15.10.04.0060.000538%Not Available
Tongue biting12.01.17.023; 17.02.05.064; 07.14.01.0130.001184%Not Available
Tachyphrenia17.03.03.007; 19.10.03.0100.003661%Not Available
Excessive eye blinking06.05.01.004; 17.17.02.0100.001184%Not Available
Defiant behaviour19.05.01.0170.001830%Not Available
Disease complication08.01.03.0870.000538%Not Available
Drug effect less than expected08.06.01.0360.006406%Not Available
Electric shock sensation17.02.07.024; 08.06.02.0230.001830%Not Available
Gait inability08.01.02.011; 17.02.05.0690.009959%Not Available
Psychotic symptom19.03.01.0120.002746%Not Available
Reduced facial expression19.01.02.021; 17.01.05.0160.002100%Not Available
Therapeutic product effect decreased08.06.01.0500.133672%Not Available
Therapeutic product effect incomplete08.06.01.0520.094964%Not Available
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