Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Etelcalcetide
Drug ID BADD_D02514
Description Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Indications and Usage Etelcalcetide is a calcium-sensing receptor agonist indicated for: Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.
Marketing Status approved; investigational
ATC Code H05BX04
DrugBank ID DB12865
KEGG ID D10676
MeSH ID C583569
PubChem ID 71511839
TTD Drug ID D07RYI
NDC Product Code 55463-0030; 55513-741; 55513-740; 52076-6227; 55513-742
UNII 60ME133FJB
Synonyms etelcalcetide hydrochloride | velcalcetide | etelcalcetide | KAI-4169 | Parsabiv | AMG-416 | AMG 416
Chemical Information
Molecular Formula C38H73N21O10S2
CAS Registry Number 1262780-97-1
SMILES CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN= C(N)N)NC(=O)C(C)NC(=O)C(CSSCC(C(=O)O)N)NC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.046918%Not Available
Abdominal pain07.01.05.0020.024929%
Abnormal dreams19.02.03.001; 17.15.02.0010.004347%Not Available
Acne23.02.01.0010.004347%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.001278%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.001918%
Angina unstable24.04.04.004; 02.02.02.0040.001278%Not Available
Arrhythmia02.03.02.0010.001918%Not Available
Arthralgia15.01.02.0010.041293%
Atrial fibrillation02.03.03.0020.003196%
Bone pain15.02.01.0010.018026%
Burning sensation17.02.06.001; 08.01.09.0290.010866%Not Available
Cardiac arrest02.03.04.0010.005753%
Cardiac failure02.05.01.0010.010866%
Cardiac failure acute02.05.01.0050.001278%Not Available
Cardiac failure congestive02.05.01.0020.003835%Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.0090.004474%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.002557%Not Available
Cerebral infarction17.08.01.004; 24.04.06.0020.003835%Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.007798%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.032344%Not Available
Cholangitis09.02.01.0020.001918%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.003196%Not Available
Diarrhoea07.02.01.0010.137301%
Disorientation17.02.05.015; 19.13.01.0020.003452%Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.047557%
Dysgeusia17.02.07.003; 07.14.03.0010.013679%
Dyspepsia07.01.02.0010.008693%
Eczema23.03.04.0060.002557%
Epilepsy17.12.03.0020.001918%Not Available
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