| Pharmaceutical Information |
| Drug Name |
Binimetinib |
| Drug ID |
BADD_D02535 |
| Description |
Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib] [A34275,L3335].
On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array BioPharma Inc.) in combination for patients with unresectable or metastatic melanoma with the BRAF V600E or V600K mutations, as detected by an FDA-approved test.[L3335] |
| Indications and Usage |
On June 27, 2018, the Food and Drug Administration approved encorafenib and binimetinib in combination patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test [L3335]. |
| Marketing Status |
approved; investigational |
| ATC Code |
L01EE03 |
| DrugBank ID |
DB11967
|
| KEGG ID |
D10604
|
| MeSH ID |
C581313
|
| PubChem ID |
10288191
|
| TTD Drug ID |
D0C4LF
|
| NDC Product Code |
70255-010; 54893-0119 |
| UNII |
181R97MR71
|
| Synonyms |
binimetinib | Mektovi | MEK162 |
|
| Chemical Information |
| Molecular Formula |
C17H15BrF2N4O3 |
| CAS Registry Number |
606143-89-9 |
| SMILES |
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO |
| Chemical Structure |
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| ADRs Induced by Drug |
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