Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Calcifediol
Drug ID BADD_D02538
Description The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Indications and Usage Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
Marketing Status approved; nutraceutical
ATC Code A11CC06; H05BX05
DrugBank ID DB00146
KEGG ID D00122
MeSH ID D002112
PubChem ID 5283731
TTD Drug ID D02VPX
NDC Product Code 45408-002; 11014-0440; 66499-0065; 70301-1001; 11014-0204
UNII P6YZ13C99Q
Synonyms Calcifediol | 25-Hydroxyvitamin D 3 | 25 Hydroxyvitamin D 3 | 25-Hydroxycholecalciferol Monohydrate | 25 Hydroxycholecalciferol Monohydrate | Monohydrate, 25-Hydroxycholecalciferol | 25-Hydroxyvitamin D3 | 25 Hydroxyvitamin D3 | Calcidiol | 25-Hydroxycholecalciferol | 25 Hydroxycholecalciferol | Calcifediol, (3 beta,5E,7E)-Isomer | Calcifediol Anhydrous | Anhydrous, Calcifediol | Dedrogyl | Hidroferol | Calcifediol, (3 alpha,5Z,7E)-Isomer | Calderol
Chemical Information
Molecular Formula C27H44O2
CAS Registry Number 19356-17-3
SMILES CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Death08.04.01.0010.043465%
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.006520%
Dry skin23.03.03.0010.002415%
Dyspnoea02.11.05.003; 22.02.01.0040.002415%
Erythema23.03.06.0010.002415%Not Available
Pruritus23.03.12.0010.002415%
Renal failure20.01.03.0050.005312%Not Available
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