| Pharmaceutical Information |
| Drug Name |
Cefiderocol |
| Drug ID |
BADD_D02541 |
| Description |
Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels.[A189057] It represents a significant addition to antibacterial treatment option as it has proven to be effective *in vitro* against multidrug resistant strains including extended spectrum β-lactamase producers and carbapenemase producing bacteria.
Cefiderocol was granted designation as a Qualified Infectious Disease Product and granted priority review status by the FDA on November 14, 2019.[L10893] It is indicated for use in complicated urinary tract infections in patients with limited or no alternative treatments available.[FDA Label] This indication was supported by a positive clinical trial composed of 448 patients with complicated urinary tract infections which demonstrated a 72.6% rate of symptom resolution and bacterial eradication with cefiderocol compared to 54.6% with the comparator, imipenem/cilastatin.[A189150] A concern noted in the trial was a 0.3% higher rate of all cause mortality, the cause of which has not been determined. |
| Indications and Usage |
Cefiderocol is indicated for the treatment of complicated urinary tract infections with or without pyelonephritis.[FDA Label] |
| Marketing Status |
approved; investigational |
| ATC Code |
J01DI04 |
| DrugBank ID |
DB14879
|
| KEGG ID |
D11302
|
| MeSH ID |
C000612166
|
| PubChem ID |
77843966
|
| TTD Drug ID |
D0Q7MA
|
| NDC Product Code |
Not Available |
| UNII |
SZ34OMG6E8
|
| Synonyms |
cefiderocol | S-649266 |
|
| Chemical Information |
| Molecular Formula |
C30H34ClN7O10S2 |
| CAS Registry Number |
1225208-94-5 |
| SMILES |
CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5
=C(C(=C(C=C5)O)O)Cl)C(=O)[O-] |
| Chemical Structure |
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| ADRs Induced by Drug |
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