| Drug Name |
Fenfluramine |
| Drug ID |
BADD_D02555 |
| Description |
Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712, A214715] Fenfluramine is a serotonergic phenethylamine originally used as an appetite suppressant until concerns regarding cardiotoxicity in obese patients lead to its withdrawal from the market in 1997.[A214694, A214718, A11906] Through its ability to modulate neurotransmission, fenfluramine has reemerged as an effective therapy against pharmacoresistant seizures, such as those involved in Dravet syndrome.[A214688, A214691, A214700]
Fenfluramine was granted initial FDA approval in 1973 prior to its withdrawal; it was granted a new FDA approval on June 25, 2020, for treatment of Dravet syndrome patients through the restricted FINTEPLA REMS program. It is currently sold under the name FINTEPLA® by Zogenix INC.[L14522] |
| Indications and Usage |
Fenfluramine is indicated for the treatment of seizures in Dravet syndrome patients aged two years and older.[L14522] |
| Marketing Status |
approved; illicit; investigational; withdrawn |
| ATC Code |
A08AA02; N03AX26 |
| DrugBank ID |
DB00574
|
| KEGG ID |
D07945
|
| MeSH ID |
D005277
|
| PubChem ID |
3337
|
| TTD Drug ID |
D09WNK
|
| NDC Product Code |
70600-024; 43376-322 |
| UNII |
2DS058H2CF
|
| Synonyms |
Fenfluramine | Fenfluramine Hydrochloride | Hydrochloride, Fenfluramine | Fenfluramine Hydrochloride, (+-)-Isomer | Pondimin | Fenfluramine, (+-)-Isomer | Fenfluramine, R-Isomer | Fenfluramine, R Isomer | Isomeride | Fintepla | Fenfluramine Hydrochloride, R-Isomer | Fenfluramine Hydrochloride, R Isomer |
