Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Magnesium
Drug ID BADD_D02569
Description Magnesium is classified as an alkaline earth metal and has 2 hydration shells.[A19349] The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.[A19349] Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens.[A188120,L2601] Magnesium is an important enzyme cofactor and is essential to several metabolic processes.[A32810] Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.[A32810] Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium.[A39559] Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).[A39559]
Indications and Usage Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies.[L2601] In medicine, various magnesium salts may be used in laxative and antacid products.[A19349] For example, [magnesium citrate] is available over-the-counter and may be used to manage occasional constipation.[L10349] [Magnesium sulfate] may be used on its own or with total parenteral nutrition to treat hypomagnesemia.[L10355] [Magnesium sulfate] is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.[A188087,L10355]
Marketing Status approved; experimental; investigational
ATC Code Not Available
DrugBank ID DB14513
KEGG ID Not Available
MeSH ID D008274
PubChem ID 5462224
TTD Drug ID D0B8QB
NDC Product Code 68428-981
UNII I38ZP9992A
Synonyms Magnesium
Chemical Information
Molecular Formula Mg
CAS Registry Number 7439-95-4
SMILES [Mg]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Memory impairment19.20.01.003; 17.03.02.0030.000441%
Middle insomnia19.02.01.003; 17.15.03.0030.000294%Not Available
Muscle rigidity15.05.04.001; 17.05.02.0050.000736%Not Available
Muscle spasms15.05.03.0040.002825%
Muscular weakness17.05.03.005; 15.05.06.0010.000294%
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.000294%
On and off phenomenon17.01.05.0040.000883%Not Available
Pain08.01.08.0040.001736%
Pain in extremity15.03.04.0100.000942%
Palpitations02.11.04.0120.000589%
Pancytopenia01.03.03.0030.000294%Not Available
Paralysis17.01.04.0040.000294%Not Available
Premature baby18.04.02.0010.001913%Not Available
Premature delivery18.07.01.0060.000795%
Premature labour18.07.01.0020.000589%Not Available
Pruritus23.03.12.0010.000294%
Pulmonary embolism24.01.06.001; 22.06.02.0010.000589%Not Available
Pyrexia08.05.02.0030.000294%
Rash pruritic23.03.13.0300.000294%Not Available
Renal failure20.01.03.0050.000294%Not Available
Respiratory distress22.02.01.0120.000294%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000589%
Restlessness19.11.02.002; 17.02.05.0210.000589%
Rhinorrhoea22.12.03.0210.000294%
Second primary malignancy16.16.01.0140.000294%
Sedation17.02.04.0050.000294%Not Available
Seizure17.12.03.0010.000441%
Shock24.06.02.0020.000294%Not Available
Sleep disorder19.02.04.0010.000441%Not Available
Somnolence17.02.04.006; 19.02.05.0030.000441%
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