| Pharmaceutical Information |
| Drug Name |
Maralixibat |
| Drug ID |
BADD_D02570 |
| Description |
Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like [odevixibat].[A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome, who are at least 1 year old.[L38834]
Previously, patients with cholestatic pruritus associated with Alagille syndrome were treated with antihistamines, [rifampin], [ursodeoxycholic acid], [cholestyramine], [naltrexone], and [sertraline] alone or in combination.[A239249] No clinical trials have been performed to assess the efficacy of these treatments for cholestatic pruritus and treatments were given based on a prescriber's clinical experience.[A239249] Surgical interventions such as partial external bile diversion and ileal exclusion have also been used as treatments.[A239249]
Maralixibat represents the first FDA approved treatment for cholestatic pruritus in patients with Alagille syndrome.
Maralixibat was granted FDA approval on 29 September 2021.[L38834] |
| Indications and Usage |
Maralixibat is indicated in the treatment of cholestatic pruritus in patients with Alagille syndrome who are at least 1 year old.[L38834] |
| Marketing Status |
approved; investigational |
| ATC Code |
Not Available |
| DrugBank ID |
DB16226
|
| KEGG ID |
D10951
|
| MeSH ID |
Not Available
|
| PubChem ID |
9831643
|
| TTD Drug ID |
DZB84T
|
| NDC Product Code |
50193-0423 |
| UNII |
UYB6UOF69L
|
| Synonyms |
Not Available |
|
| Chemical Information |
| Molecular Formula |
C40H56N3O4S+ |
| CAS Registry Number |
716313-53-0 |
| SMILES |
CCCCC1(CS(=O)(=O)C2=C(C=C(C=C2)N(C)C)C(C1O)C3=CC=C(C=C3)OCC4=CC=C(C=C4)C[N+]56CC
N(CC5)CC6)CCCC |
| Chemical Structure |
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| ADRs Induced by Drug |
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