Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Maribavir
Drug ID BADD_D02571
Description Maribavir is an inhibitor of the cytomegalovirus (CMV; HHV5) pUL97 kinase which is used to treat CMV infections in patients post-transplantation.[L39322] Most standard CMV therapies, such as [ganciclovir] or [foscarnet], target CMV DNA polymerase - while generally effective, these medications tend to promote the development of CMV resistance to DNA polymerase-based therapies, and their use is often limited by toxicities like myelosuppression and renal injury.[A242557] Maribavir is novel in that it instead targets the CMV pUL97 kinase, thereby providing an effective alternative treatment option in cases of resistant infections. Maribavir was approved by the FDA in November 2021, under the name Livtencity (Takeda), for the treatment of resistant CMV infections in post-transplant patients.[L39327]
Indications and Usage Maribavir is indicated for the treatment of adult and pediatric patients (weighing >35kg and at least 12 years old) with post-transplant cytomegalovirus (CMV) infection which is refractory to standard treatment with [ganciclovir], [valganciclovir], [cidofovir], or [foscarnet].[L39322]
Marketing Status approved; investigational
ATC Code J05AX10
DrugBank ID DB06234
KEGG ID D04859
MeSH ID C400401
PubChem ID 471161
TTD Drug ID D07WXI
NDC Product Code 64764-800; 58567-106
UNII PTB4X93HE1
Synonyms maribavir | benzimidavir | 5,6-dichloro-2-(isopropylamino)-1-beta-L-ribofuranosylbenzimidazole | 1263W94 | 1263-W-94 | GW 1263 | GW-1263 | BW 1263W94 | BW-1263W94 | GW 257406X | GW257406X | GW-257406X
Chemical Information
Molecular Formula C15H19Cl2N3O4
CAS Registry Number 176161-24-3
SMILES CC(C)NC1=NC2=CC(=C(C=C2N1C3C(C(C(O3)CO)O)O)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancytopenia01.03.03.0030.000282%Not Available
Pyrexia08.05.02.0030.001242%
Rash23.03.13.0010.002060%Not Available
Renal disorder20.01.02.0020.000423%Not Available
Renal failure20.01.03.0050.000282%Not Available
Tremor17.01.06.0020.000762%
Vomiting07.01.07.0030.001327%
Drug resistance08.06.01.0050.002992%Not Available
Cardiac disorder02.11.01.0030.000706%Not Available
Feeding disorder14.03.02.003; 19.09.01.0030.000282%Not Available
Adverse drug reaction08.06.01.0090.000903%Not Available
Renal impairment20.01.03.0100.000423%Not Available
Illness08.01.03.0910.001185%Not Available
Myelosuppression01.03.03.0150.000282%Not Available
Taste disorder17.02.07.029; 07.14.03.0040.008214%Not Available
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