| Pharmaceutical Information |
| Drug Name |
Tazemetostat |
| Drug ID |
BADD_D02598 |
| Description |
Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.[L11476] Tazemetostat was first named in literature as EPZ-6438.[A190363]
Tazemetaostat was granted FDA approval on 23 January 2020.[L11476] |
| Indications and Usage |
Tazemetostat is indicated to treat adult and pediatric patients 16 years and older with metastatic or locally advanced epithelioid sarcoma that is not eligible for complete resection.[L11476] |
| Marketing Status |
approved; investigational |
| ATC Code |
L01XX72 |
| DrugBank ID |
DB12887
|
| KEGG ID |
D11444
|
| MeSH ID |
C000593333
|
| PubChem ID |
66558664
|
| TTD Drug ID |
D00EQL
|
| NDC Product Code |
72607-100 |
| UNII |
Q40W93WPE1
|
| Synonyms |
tazemetostat | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(oxan-4-yl)amino)-4-methyl-4'-((morpholin-4-yl)methyl)(1,1'-biphenyl)-3-carboxamide | EPZ-6438 monohydrochloride | tazemetostat dihydrobromide | (1,1'-biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)-, hydrobromide (1:2) | tazemetostat hydrochloride | (1,1'-biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)-, hydrochloride (1:1) | tazemetostat monohydrochloride | tazemetostat hydrobromide | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(oxan-4-yl)amino)-4-methyl-4'-((morpholin-4-yl)methyl)(1,1'-biphenyl)-3-carboxamide monohydrobromide | tazemetostat monohydrobromide | EPZ-6438 monohydrobromide | EPZ-6438 trihydrochloride | EZ-438 | EZ438 | EPZ-6438 dihydrobromide | E 7438 | E7438 | E-7438 hydrobromide | Tazverik | EPZ-6438 | tazemetostat trihydrochloride |
|
| Chemical Information |
| Molecular Formula |
C34H44N4O4 |
| CAS Registry Number |
1403254-99-8 |
| SMILES |
CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5 |
| Chemical Structure |
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| ADRs Induced by Drug |
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