| Pharmaceutical Information |
| Drug Name |
Trifarotene |
| Drug ID |
BADD_D02601 |
| Description |
Trifarotene is a topical retinoid cream used in the treatment of acne vulgaris that was first approved for use in the United States in October 2019.[L9013] Retinoids are a class of medications structurally and functionally analogous to [vitamin A], though later generation retinoids such as trifarotene and [adapalene] bear little structural resemblance to vitamin A and are analogous only in function.[A187081] Trifarotene is considered the first of the "fourth-generation" retinoids due to its uniquely selective activity - this selectivity appears to confer improved efficacy and reduced side effects as compared to older, less selective retinoids.[A187054] |
| Indications and Usage |
Trifarotene is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.[L9013] |
| Marketing Status |
approved; investigational |
| ATC Code |
D10AD06 |
| DrugBank ID |
DB12808
|
| KEGG ID |
D11225
|
| MeSH ID |
C000629420
|
| PubChem ID |
11518241
|
| TTD Drug ID |
D06FOU
|
| NDC Product Code |
17337-0432; 0299-5935 |
| UNII |
0J8RN2W0HK
|
| Synonyms |
trifarotene | Aklief | CD5789 |
|
| Chemical Information |
| Molecular Formula |
C29H33NO4 |
| CAS Registry Number |
895542-09-3 |
| SMILES |
CC(C)(C)C1=C(C=CC(=C1)C2=C(C=CC(=C2)C3=CC=C(C=C3)C(=O)O)OCCO)N4CCCC4 |
| Chemical Structure |
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| ADRs Induced by Drug |
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