| Pharmaceutical Information |
| Drug Name |
Ubrogepant |
| Drug ID |
BADD_D02604 |
| Description |
Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults.[L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine.[L10959] Several oral small molecule CGRP receptor antagonists, belonging to a class of medications referred to as "gepants", have been investigated for migraines, but only ubrogepant and [rimegepant] remain in clinical development.[A189207,A189213] Previous agents within this class were efficacious but limited by liver toxicity - this led to the development of ubrogepant, which was designed to be a hepatoxicity-free alternative to its predecessors.[A189195] Several parenteral monoclonal antibodies acting against the CGRP pathway (e.g. [erenumab], [fremanezumab], [galcanezumab]) have also been approved in recent years.[A189207]
Compared to the current standard of therapy for migraine treatment, namely triptans such as [sumatriptan] and [almotriptan], CGRP antagonists present several advantages.[A189195] They appear to be better tolerated, do not contribute to medication overuse headaches, and carry no apparent cardiovascular risk, making them suitable for use in patients with cardiovascular disease.[A189195] The development of oral gepants, including ubrogepant, may therefore constitute a significant advance in migraine headache treatment and may become the new standard of therapy in the treatment of this debilitating condition. |
| Indications and Usage |
Ubrogepant is indicated for the acute treatment of migraine with or without aura in adults.[L10926] |
| Marketing Status |
approved; investigational |
| ATC Code |
N02CD04 |
| DrugBank ID |
DB15328
|
| KEGG ID |
D10673
|
| MeSH ID |
C000615620
|
| PubChem ID |
68748835
|
| TTD Drug ID |
D07GXR
|
| NDC Product Code |
0023-6499; 69037-0077; 0023-6501; 0023-6502; 0023-6498 |
| UNII |
AD0O8X2QJR
|
| Synonyms |
ubrogepant | ubrelvy | MK-1602 | 1',2',5,7-tetrahydro-N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl)-2'-oxo-, (6S)- spiro(6H-cyclopenta(b)pyridine-6,3'-(3H)pyrrolo(2,3-b)pyridine)-3-carboxamide |
|
| Chemical Information |
| Molecular Formula |
C29H26F3N5O3 |
| CAS Registry Number |
1374248-77-7 |
| SMILES |
CC1C(CC(C(=O)N1CC(F)(F)F)NC(=O)C2=CC3=C(CC4(C3)C5=C(NC4=O)N=CC=C5)N=C2)C6=CC=CC=
C6 |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
|
|
|
