| Drug Name |
Alfacalcidol |
| Drug ID |
BADD_D02610 |
| Description |
Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of [vitamin D].[A234044] It plays an essential function in calcium homeostasis and bone metabolism. Alfacaldisol is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body, or most importantly, the kidneys and bones. The pharmacological actions of alfacalcidol are prolonged than vitamin D because a negative feedback mechanism regulates the final activation step of vitamin D in the kidneys.[A175348,A175351]
Alfacalcidol is available in oral and intravenous formulations. In Canada, it is marketed as ONE-ALPHA, which manages hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in adults with chronic renal failure.[L33284] In approving European countries, alfacalcidol is also indicated for managing nutritional and malabsorptive rickets and osteomalacia, vitamin D-dependent rickets and osteomalacia, and hypophosphataemic vitamin D resistant rickets and osteomalacia.[L33364,L33369] |
| Indications and Usage |
Alfacalcidol is indicated in adult patients with chronic renal failure for the management of hypocalcemia, secondary hyperparathyroidism, or osteodystrophy.[L33284]
Alfacalcidol is indicated in the management of nutritional and malabsorptive rickets and osteomalacia, vitamin D-dependent rickets and osteomalacia, and hypophosphataemic vitamin D resistant rickets and osteomalacia.[L33364,L33369] |
| Marketing Status |
approved; nutraceutical |
| ATC Code |
A11CC03 |
| DrugBank ID |
DB01436
|
| KEGG ID |
D01518
|
| MeSH ID |
C008088
|
| PubChem ID |
5282181
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
Not Available |
| UNII |
URQ2517572
|
| Synonyms |
alfacalcidol | 1 alpha-hydroxyvitamin D3 | 1-alpha-oxycholecalciferol | 1-hydroxycholecalciferol | alphacalcidol | 1 alpha-hydroxycholecalciferol | 1alpha-OHD3 | 1-hydroxycholecalciferol, (1beta)-(5Z)-isomer | 1-hydroxycholecalciferol, (1beta,3beta-(5E,7E))-isomer | 1-hydroxycholecalciferol, aluminum salt | Oksidevit | Bondiol | Eenalfadrie | Etalpha | Un-Alfa | EinsAlpha | One-Alpha | 1-hydroxycholecalciferol, (1alpha,3alpha-(5Z,7E))-isomer | AlfaD |
