Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cisapride
Drug ID BADD_D02618
Description In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.
Indications and Usage For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Marketing Status approved; investigational; withdrawn
ATC Code A03FA02
DrugBank ID DB00604
KEGG ID D00274; D02092
MeSH ID D020117
PubChem ID 6917698
TTD Drug ID D0BD8D
NDC Product Code 12578-431; 60592-031
UNII UVL329170W
Synonyms Cisapride | R-51619 | R 51619 | R51619 | Propulsid
Chemical Information
Molecular Formula C23H29ClFN3O4
CAS Registry Number 81098-60-4
SMILES COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002--Not Available
Cardiac arrest02.03.04.001--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Death08.04.01.001--
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.11.04.006; 24.06.02.007--
Dyspnoea02.11.05.003; 22.02.01.004--
Hyperkinesia17.01.02.008--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Palpitations02.11.04.012--
Torsade de pointes02.03.04.005--Not Available
Ventricular fibrillation02.03.04.008--
Vomiting07.01.07.003--
Cardiac disorder02.11.01.003--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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ADReCS-Target
Drug Name ADR Term Target
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