Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methyl salicylate
Drug ID BADD_D02627
Description Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments. It forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. It is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic in mouthwash solutions.
Indications and Usage Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.
Marketing Status approved; vet_approved
ATC Code Not Available
DrugBank ID DB09543
KEGG ID D01087
MeSH ID C033069
PubChem ID 4133
TTD Drug ID D0Z0AA
NDC Product Code 72937-001; 71417-004; 55758-108; 82108-114; 43251-2400; 53145-047; 53145-081; 53145-303; 68788-8064; 79643-003; 57598-111; 61734-300; 55758-360; 57598-112; 63255-210; 70211-704; 82944-101; 72917-1000; 53145-082; 70336-718; 50765-4691; 53145-401; 55758-378; 68788-7925; 10357-700; 51551-0310; 61476-100; 81877-620; 14534-227; 10107-420; 50488-1015; 50488-2010; 53145-403; 55758-109; 48251-0220; 52099-8000; 82165-100; 83517-001; 53145-705; 55758-377; 63187-078; 72937-110; 55758-107
UNII LAV5U5022Y
Synonyms methyl salicylate | methylsalicylate | Rheumabal | methyl salicylate sodium salt | Metsal Liniment | Hewedolor | Linsal
Chemical Information
Molecular Formula C8H8O3
CAS Registry Number 119-36-8
SMILES COC(=O)C1=CC=CC=C1O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Cough22.02.03.001--
Dermatitis bullous23.03.01.002--
Dyspnoea02.11.05.003; 22.02.01.004--
Erythema23.03.06.001--Not Available
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pulmonary fibrosis22.01.02.006--
Vomiting07.01.07.003--
Peripheral swelling02.05.04.015; 08.01.03.053--Not Available
Skin burning sensation23.03.03.021; 17.02.06.009--Not Available
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