Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rupatadine
Drug ID BADD_D02635
Description Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria. It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for adult use and liquid formulation for pediatric use.
Indications and Usage For the symptomatic relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and perennial allergic rhinitis in patients 2 years of age and older [FDA Label]. Also used for the symptomatic relief of chronic spontaneous urticaria in patients 2 years of age and older.
Marketing Status approved
ATC Code R06AX28
DrugBank ID DB11614
KEGG ID D07407
MeSH ID C103639
PubChem ID 133017
TTD Drug ID D0S1CQ
NDC Product Code Not Available
UNII 2AE8M83G3E
Synonyms rupatadine | 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine | UR 12592 | UR-12592
Chemical Information
Molecular Formula C26H26ClN3
CAS Registry Number 158876-82-5
SMILES CC1=CC(=CN=C1)CN2CCC(=C3C4=C(CCC5=C3N=CC=C5)C=C(C=C4)Cl)CC2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Somnolence19.02.05.003; 17.02.04.006--
Stress19.06.02.004--Not Available
Swelling08.01.03.015--Not Available
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.018--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.11.04.015--
Throat irritation22.12.03.029; 07.05.05.037--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Wheezing22.03.01.009--
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Inflammation10.02.01.089; 08.01.05.007--Not Available
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Skin plaque23.03.03.044--Not Available
Chronic spontaneous urticaria23.04.02.011; 10.01.06.011--Not Available
Illness08.01.03.091--Not Available
Therapeutic product effect incomplete08.06.01.052--Not Available
Therapy non-responder08.06.01.063--Not Available
Therapy partial responder08.06.01.064--Not Available
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