Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02495Duvelisib0.000548%
BADD_D02498Abemaciclib0.003873%
BADD_D02503Telotristat ethyl-
BADD_D02509Brigatinib0.000806%
BADD_D02510Rucaparib0.034787%
BADD_D02511Siponimod--
BADD_D02515Pexidartinib0.000492%
BADD_D02517Enasidenib0.002283%
BADD_D02521Sodium zirconium cyclosilicate0.035934%
BADD_D02524Ivosidenib0.003022%
BADD_D02526Larotrectinib0.000851%
BADD_D02529Atogepant0.004402%
BADD_D02542Cenobamate0.000336%
BADD_D02548Darolutamide0.000501%
BADD_D02549Deucravacitinib0.001230%
BADD_D02550Diroximel fumarate0.002869%
BADD_D02551Docusate0.000110%
BADD_D02552Encorafenib0.000381%
BADD_D02553Entrectinib0.000470%
BADD_D02554Fedratinib0.001198%
BADD_D02556Ferrous cation0.010792%
BADD_D02559Glasdegib0.000112%
BADD_D02569Magnesium0.000883%
BADD_D02571Maribavir0.000565%
BADD_D02573Mobocertinib0.000168%
BADD_D02576Opicapone0.002495%
BADD_D02582Pemigatinib0.000302%
BADD_D02585Pralsetinib0.000112%
BADD_D02587Relugolix0.001869%
BADD_D02589Revefenacin0.000052%
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