Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Endometrial hyperplasia
ADR ID BADD_A01490
ADR Hierarchy
21      Reproductive system and breast disorders
21.07      Uterine, pelvic and broad ligament disorders
21.07.01      Uterine disorders NEC
21.07.01.002      Endometrial hyperplasia
Description Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant. | A benign form of endometrial hyperplasia with increased number of cells with atypia. The atypical cells are large and irregular and have an increased nuclear/cytoplasmic ratio. The risk of progression to endometrial carcinoma rises with the increasing degree of cell atypia. | A benign form of endometrial hyperplasia with crowded endometrial glands and little stroma between the glands. Complex hyperplasia has low risk of progression to endometrial carcinoma. | A benign form of endometrial hyperplasia with increased number of endometrial glands and thickened endometrium. Simple hyperplasia has little risk of progression to endometrial carcinoma. [MeSH]
MedDRA Code 10014755
MeSH ID D004714
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Adenomatous hyperplasia of endometrium | Cystic hyperplasia of endometrium | Endometrial cystic hyperplasia | Endometrial hyperplasia | Endometrium pseudodecidual | Hyperplasia endometrial | Endometrioid intraepithelial neoplasia | Endometrial Hyperplasia | Endometrial Hyperplasias | Hyperplasia, Endometrial | Hyperplasias, Endometrial | Atypical Endometrial Hyperplasia | Atypical Endometrial Hyperplasias | Endometrial Hyperplasia, Atypical | Endometrial Hyperplasias, Atypical | Hyperplasia, Atypical Endometrial | Hyperplasias, Atypical Endometrial | Complex Endometrial Hyperplasia | Complex Endometrial Hyperplasias | Endometrial Hyperplasia, Complex | Endometrial Hyperplasias, Complex | Hyperplasia, Complex Endometrial | Hyperplasias, Complex Endometrial | Simple Endometrial Hyperplasia | Endometrial Hyperplasia, Simple | Endometrial Hyperplasias, Simple | Hyperplasia, Simple Endometrial | Hyperplasias, Simple Endometrial | Simple Endometrial Hyperplasias
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000044%
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00528Conjugated estrogens--
BADD_D00529Copper-
BADD_D00648Diazepam--
BADD_D00793Equilin sulfate--
BADD_D00820Esterified estrogens--
BADD_D00821Estradiol0.000083%
BADD_D00822Estradiol acetate--
BADD_D00823Estradiol cypionate--
BADD_D00824Estradiol hemihydrate--
BADD_D00825Estradiol valerate--
BADD_D00830Estrofen--
BADD_D00831Estrogens--
BADD_D00832Estrogens conjugated synthetic a--
BADD_D00833Estrogens conjugated synthetic b--
BADD_D00834Estrone--
BADD_D00835Estrone sulfate--
BADD_D00836Estropipate--
BADD_D00861Exemestane--
BADD_D01250Lasofoxifene--
BADD_D01257Letrozole--
BADD_D01281Levonorgestrel0.007754%
BADD_D01366Medroxyprogesterone acetate0.000262%
BADD_D01401Metformin0.000005%
BADD_D01463Mifepristone0.000396%
BADD_D01586Norethindrone acetate--
BADD_D01852Progesterone--
BADD_D02111Tamoxifen--
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