Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Estrone
Drug ID BADD_D00834
Description Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Indications and Usage For management of perimenopausal and postmenopausal symptoms.
Marketing Status approved
ATC Code G03CA07; G03CC04
DrugBank ID DB00655
KEGG ID D00067
MeSH ID D004970
PubChem ID 5870
TTD Drug ID D00ZFP
NDC Product Code 49452-2795; 0220-2129; 71052-548; 0220-2116; 44132-011; 51927-1709; 44132-003; 63083-1516; 38779-0891; 22552-0022; 51552-0445; 0220-2117
UNII 2DI9HA706A
Synonyms Estrone | Estrone, (8 alpha)-Isomer | Estrone, (9 beta)-Isomer | Wehgen | Folliculin (Hormone) | Kestrone | Unigen | Estrone, (+-)-Isomer | Estrovarin
Chemical Information
Molecular Formula C18H22O2
CAS Registry Number 53-16-7
SMILES CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Asthma10.01.03.010; 22.03.01.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Breast discharge21.05.05.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chloasma18.08.02.002; 23.05.01.001--Not Available
Chorea17.01.01.001--Not Available
Dementia19.20.02.001; 17.03.01.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Dysmenorrhoea21.01.01.002--
Ectropion of cervix21.06.01.004--Not Available
Endometrial cancer21.07.02.002; 16.12.02.001--Not Available
Endometrial hyperplasia21.07.01.002--Not Available
Epilepsy17.12.03.002--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Erythema nodosum10.02.01.020; 23.07.02.001--Not Available
Fibrocystic breast disease21.05.04.018; 16.14.01.003--Not Available
Flatulence07.01.04.002--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gallbladder disorder09.03.02.001--Not Available
Haemangioma16.02.01.002; 24.03.06.004--Not Available
Headache17.14.01.001--
Hirsutism23.02.04.001; 05.05.01.005--
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