Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Extrapyramidal disorder
ADR ID BADD_A01568
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.02      Dyskinesias and movement disorders NEC
17.01.02.007      Extrapyramidal disorder
Description A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. [CTCAE] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA. [MeSH]
MedDRA Code 10015832
MeSH ID D001480
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Benign shuddering attacks | Drug-induced extrapyramidal side effects | Extrapyramidal disorder | Extrapyramidal disorder (NOS) | Extrapyramidal disorder NEC | Extrapyramidal symptoms | Extrapyramidal syndrome | Extrapyramidal syndrome (NOS) | Other and unspecified extrapyramidal diseases and abnormal movement disorders | Other extrapyramidal disease and abnormal movement disorders | Other extrapyramidal diseases and abnormal movement disorders | Syndrome extrapyramidal | Unspecified extrapyramidal disease and abnormal movement disorder | Extrapyramidal disorder aggravate | Extrapyramidal disorder aggravated | Basal Ganglia Diseases | Basal Ganglia Disease | Basal Ganglia Disorders | Basal Ganglia Disorder | Extrapyramidal Disorders | Extrapyramidal Disorder | Lenticulostriate Disorders | Lenticulostriate Disorder
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00476Citalopram hydrobromide--
BADD_D00499Clomipramine0.001932%
BADD_D00500Clomipramine hydrochloride--
BADD_D00511Clozapine--
BADD_D00545Cyclobenzaprine--
BADD_D00546Cyclobenzaprine hydrochloride--
BADD_D00612Desipramine--
BADD_D00613Desipramine hydrochloride--
BADD_D00615Desloratadine--
BADD_D00621Desvenlafaxine--
BADD_D00622Desvenlafaxine succinate--
BADD_D00648Diazepam0.000277%
BADD_D00649Diazoxide--
BADD_D00674Diltiazem--
BADD_D00675Diltiazem hydrochloride--
BADD_D00686Diphenhydramine0.000269%
BADD_D00704Dolutegravir sodium0.000282%
BADD_D00705Domperidone--
BADD_D00706Donepezil0.000247%
BADD_D00707Donepezil hydrochloride--
BADD_D00714Dothiepin hydrochloride--
BADD_D00720Doxepin--
BADD_D00721Doxepin hydrochloride--
BADD_D00731Droperidol--
BADD_D00734Duloxetine--
BADD_D00735Duloxetine hydrochloride--
BADD_D00809Escitalopram0.000076%
BADD_D00810Escitalopram oxalate--
BADD_D00871Felbamate--
BADD_D00879Fentanyl--
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ADReCS-Target
ADR Term Drug Name Target