Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Extrapyramidal disorder
ADR ID BADD_A01568
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.02      Dyskinesias and movement disorders NEC
17.01.02.007      Extrapyramidal disorder
Description A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. [CTCAE] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA. [MeSH]
MedDRA Code 10015832
MeSH ID D001480
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Benign shuddering attacks | Drug-induced extrapyramidal side effects | Extrapyramidal disorder | Extrapyramidal disorder (NOS) | Extrapyramidal disorder NEC | Extrapyramidal symptoms | Extrapyramidal syndrome | Extrapyramidal syndrome (NOS) | Other and unspecified extrapyramidal diseases and abnormal movement disorders | Other extrapyramidal disease and abnormal movement disorders | Other extrapyramidal diseases and abnormal movement disorders | Syndrome extrapyramidal | Unspecified extrapyramidal disease and abnormal movement disorder | Extrapyramidal disorder aggravate | Extrapyramidal disorder aggravated | Basal Ganglia Diseases | Basal Ganglia Disease | Basal Ganglia Disorders | Basal Ganglia Disorder | Extrapyramidal Disorders | Extrapyramidal Disorder | Lenticulostriate Disorders | Lenticulostriate Disorder
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02200Thioridazine--
BADD_D02201Thioridazine hydrochloride--
BADD_D02203Thiotepa--
BADD_D02204Thiothixene--
BADD_D02241Tolcapone--
BADD_D02266Trazodone--
BADD_D02267Trazodone hydrochloride--
BADD_D02281Trifluoperazine--
BADD_D02282Trifluoperazine hydrochloride--
BADD_D02294Trimipramine--
BADD_D02295Trimipramine maleate--
BADD_D02329Valproic acid0.001608%
BADD_D02337Varenicline--
BADD_D02346Venlafaxine0.000080%
BADD_D02348Verapamil--
BADD_D02349Verapamil hydrochloride--
BADD_D02369Voriconazole--
BADD_D02389Ziprasidone hydrochloride--
BADD_D02390Ziprasidone hydrochloride monohydrate--
BADD_D02391Ziprasidone mesylate--
BADD_D02398Zuclopenthixol--
BADD_D02439Levodopa0.000367%
BADD_D02451Pimavanserin0.006507%
BADD_D02565Lumateperone0.000745%
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ADReCS-Target
ADR Term Drug Name Target