Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hepatic necrosis
ADR ID BADD_A02009
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.002      Hepatic necrosis
Description A disorder characterized by a necrotic process occurring in the hepatic parenchyma. [CTCAE]
MedDRA Code 10019692
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute and subacute necrosis of liver | Hepatic lobule necrosis | Hepatic necrosis | Hepatic necrosis extensive | Hepatitis necrotizing | Liver necrosis | Necrosis hepatocellular | Necrosis liver | Necrosis liver focal | Subacute hepatic necrosis | Hepatitis necrotising
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01546Nefazodone--
BADD_D01547Nefazodone hydrochloride--
BADD_D01557Nevirapine--
BADD_D01576Nitrofurantoin--
BADD_D01577Nitrofurantoin (macrocrystals)--
BADD_D01578Nitrofurantoin (monohydrate/macrocrystals)--
BADD_D01587Norfloxacin--
BADD_D01588Nortriptyline--
BADD_D01598Ofloxacin--
BADD_D01599Olanzapine0.000210%
BADD_D01607Olsalazine--
BADD_D01614Omeprazole--
BADD_D01615Omeprazole magnesium--
BADD_D01624Orlistat0.005655%
BADD_D01634Oxandrolone--
BADD_D01637Oxcarbazepine0.000170%
BADD_D01647Oxymetholone--
BADD_D01653Paclitaxel--
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01682Paroxetine impurity a--
BADD_D01687Pazopanib0.000112%
BADD_D01765Phenytoin0.000574%
BADD_D01824Pravastatin--
BADD_D01825Pravastatin sodium--
BADD_D01831Prednisolone0.000035%
BADD_D01834Prednisone0.000013%
BADD_D01841Probenecid--
BADD_D01852Progesterone--
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ADReCS-Target
ADR Term Drug Name Target