Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hyperkeratosis
ADR ID BADD_A02126
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.01      Cornification and dystrophic skin disorders
23.01.01      Hyperkeratoses
23.01.01.001      Hyperkeratosis
Description A disorder characterized by a thickening of the outer layer of the skin. [CTCAE] Localized hyperplasia of the horny layer of the epidermis due to pressure or friction. (Dorland, 27th ed) [MeSH]
MedDRA Code 10020649
MeSH ID D002145; D002146; D007642; D015776
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acquired keratoderma | Callosities | Callosity | Callus | Corns | Corns and callosities | Cutaneous horn | Erythrokeratoderma | Foot callus | Hard corn | Hyperkeratosis | Keratoderma | Keratoderma, acquired | Keratosis | Skin keratosis | Soft corn | Tyloma | Tylosis | Skin callus | Clavus | Heloma molle
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01213Isotretinoin--
BADD_D01252Leflunomide0.000428%
BADD_D01254Lenvatinib0.000358%
BADD_D01260Leuprolide acetate0.004876%
BADD_D01275Levofloxacin0.000042%
BADD_D01378Memantine--
BADD_D01418Methotrexate--
BADD_D01508Mycophenolic acid0.000951%
BADD_D01563Nicotinate--
BADD_D01567Nilotinib0.000168%
BADD_D01653Paclitaxel0.000280%
BADD_D01656Paliperidone--
BADD_D01687Pazopanib0.000851%
BADD_D01783Pirfenidone0.000530%
BADD_D01799Ponatinib0.000112%
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01831Prednisolone0.000052%
BADD_D01834Prednisone0.000024%
BADD_D01909Ramipril0.000093%
BADD_D01922Regorafenib0.004656%
BADD_D01951Risperidone--
BADD_D01956Rivastigmine tartrate--
BADD_D01966Ropinirole--
BADD_D02058Sorafenib0.003873%
BADD_D02100Sunitinib0.002843%
BADD_D02104Tacrine hydrochloride--
BADD_D02105Tacrolimus0.000594%
BADD_D02106Tadalafil0.000293%
BADD_D02160Terbinafine0.000223%
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