Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Idiopathic pulmonary fibrosis
ADR ID BADD_A02238
ADR Hierarchy
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.034      Idiopathic pulmonary fibrosis
22      Respiratory, thoracic and mediastinal disorders
22.01      Lower respiratory tract disorders (excl obstruction and infection)
22.01.02      Parenchymal lung disorders NEC
22.01.02.014      Idiopathic pulmonary fibrosis
Description A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. [MeSH]
MedDRA Code 10021240
MeSH ID D054990; D011658
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Alveolitis fibrosing | Cryptogenic fibrosing alveolitis | Fibrosing alveolitis | Fibrosing alveolitis (idiopathic) | Idiopathic fibrosing alveolitis | Idiopathic pulmonary fibrosis | Exacerbation of idiopathic pulmonary fibrosis | Idiopathic Pulmonary Fibrosis | Idiopathic Pulmonary Fibroses | Pulmonary Fibroses, Idiopathic | Familial Idiopathic Pulmonary Fibrosis | Fibrocystic Pulmonary Dysplasia | Dysplasia, Fibrocystic Pulmonary | Dysplasias, Fibrocystic Pulmonary | Fibrocystic Pulmonary Dysplasias | Pulmonary Dysplasia, Fibrocystic | Pulmonary Dysplasias, Fibrocystic | Fibrosing Alveolitis, Cryptogenic | Hamman-Rich Disease | Disease, Hamman-Rich | Diseases, Hamman-Rich | Hamman Rich Disease | Hamman-Rich Diseases | Interstitial Pneumonitis, Usual | Interstitial Pneumonitides, Usual | Pneumonitides, Usual Interstitial | Pneumonitis, Usual Interstitial | Usual Interstitial Pneumonitides | Usual Interstitial Pneumonitis | Pulmonary Fibrosis, Idiopathic | Usual Interstitial Pneumonia | Interstitial Pneumonia, Usual | Interstitial Pneumonias, Usual | Usual Interstitial Pneumonias | Idiopathic Fibrosing Alveolitis, Chronic Form | Cryptogenic Fibrosing Alveolitis | Cryptogenic Fibrosing Alveolitides | Fibrosing Alveolitides, Cryptogenic | Idiopathic Pulmonary Fibrosis, Familial
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00032Acetylcysteine0.000298%
BADD_D00100Ambrisentan0.000542%
BADD_D00115Amiodarone--
BADD_D00280Bleomycin--
BADD_D00480Clarithromycin0.000223%
BADD_D00551Cyclosporine0.000111%
BADD_D01009Gemcitabine0.000112%
BADD_D01218Ivabradine0.000085%
BADD_D01245Lansoprazole0.000099%
BADD_D01336Macitentan0.000361%
BADD_D01397Mesalamine--
BADD_D01401Metformin0.000049%
BADD_D01433Methylprednisolone0.000176%
BADD_D01445Metoprolol0.000043%
BADD_D01783Pirfenidone0.011067%
BADD_D02026Simvastatin0.000218%
BADD_D02093Sulfasalazine--
BADD_D02113Tamsulosin0.000198%
BADD_D02147Telmisartan0.000260%
BADD_D02192Thalidomide0.000241%
BADD_D02268Treprostinil0.000123%
BADD_D02331Valsartan--
BADD_D02470Nintedanib0.027602%
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