Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Lactic acidosis
ADR ID BADD_A02470
ADR Hierarchy
14      Metabolism and nutrition disorders
14.01      Acid-base disorders
14.01.01      Metabolic acidoses (excl diabetic acidoses)
14.01.01.002      Lactic acidosis
Description Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE. [MeSH]
MedDRA Code 10023676
MeSH ID D000140
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acidosis lactic | Lactic acidosis | Lactic acidosis syndrome | Metformin associated lactic acidosis | Acidosis, Lactic | Lactic Acidosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01133Ifosfamide0.000112%
BADD_D01149Indapamide0.000377%
BADD_D01191Ipratropium0.000785%
BADD_D01204Isoniazid0.011119%
BADD_D01205Isoprenaline0.000064%
BADD_D01231Ketoprofen0.002240%
BADD_D01242Lamivudine--
BADD_D01258Leucovorin0.002478%
BADD_D01262Levalbuterol0.000193%
BADD_D01295Linezolid0.201706%
BADD_D01392Mercaptopurine0.001041%
BADD_D01401Metformin0.013871%
BADD_D01414Methimazole0.000202%
BADD_D01445Metoprolol0.000053%
BADD_D01484Modafinil0.000617%
BADD_D01583Norepinephrine--
BADD_D01701Pemetrexed0.000224%
BADD_D01752Phenobarbital0.000325%
BADD_D01760Phenylbutyric acid--
BADD_D01835Pregabalin--
BADD_D01854Promethazine0.000211%
BADD_D01856Propafenone0.000418%
BADD_D01864Propofol0.001429%
BADD_D01895Quinine0.000734%
BADD_D01909Ramipril0.000653%
BADD_D01924Repaglinide0.005007%
BADD_D01933Ribavirin--
BADD_D01940Rilpivirine0.000282%
BADD_D01952Ritonavir0.000735%
BADD_D01992Saxagliptin0.000491%
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