Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Muscle contractions involuntary
ADR ID BADD_A02877
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.03      Muscle related signs and symptoms NEC
15.05.03.008      Muscle contractions involuntary
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.03      Neuromuscular disorders NEC
17.05.03.001      Muscle contractions involuntary
Description Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294) [MeSH]
MedDRA Code 10028293
MeSH ID D005207
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Contraction skeletal muscle | Fasciculation | Fasciculation skeletal muscle | Fibrillation skeletal muscle | Muscle contractions involuntary | Muscle fasciculation | Muscle fibrillation | Fasciculations | Fasciculation, Muscular | Fasciculations, Muscular | Muscular Fasciculation | Muscular Fasciculations | Fasciculation, Tongue | Fasciculations, Tongue | Tongue Fasciculation | Tongue Fasciculations | Fasciculation, Benign | Benign Fasciculation | Benign Fasciculations | Fasciculations, Benign | Fasciculation, Skeletal Muscle | Fasciculations, Skeletal Muscle | Muscle Fasciculation, Skeletal | Muscle Fasciculations, Skeletal | Skeletal Muscle Fasciculation | Skeletal Muscle Fasciculations
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01275Levofloxacin0.000443%
BADD_D01285Levothyroxine0.000005%
BADD_D01303Lithium carbonate--
BADD_D01304Lithium cation--
BADD_D01305Lithium hydroxide--
BADD_D01378Memantine--
BADD_D01379Memantine hydrochloride--
BADD_D01405Methadone0.000530%
BADD_D01428Methylergonovine0.002243%
BADD_D01431Methylphenidate--
BADD_D01433Methylprednisolone0.000179%
BADD_D01442Metoclopramide0.000725%
BADD_D01483Moclobemide--
BADD_D01498Morphine0.000301%
BADD_D01501Moxifloxacin--
BADD_D01535Naratriptan--
BADD_D01536Naratriptan hydrochloride--
BADD_D01553Neostigmine--
BADD_D01554Neostigmine methylsulfate--
BADD_D01599Olanzapine0.000526%
BADD_D01633Oxaliplatin0.000560%
BADD_D01637Oxcarbazepine--
BADD_D01645Oxycodone--
BADD_D01656Paliperidone--
BADD_D01668Pantoprazole0.000016%
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01682Paroxetine impurity a--
BADD_D01683Paroxetine mesylate--
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