Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Osteoporosis
ADR ID BADD_A03222
ADR Hierarchy
14      Metabolism and nutrition disorders
14.04      Bone, calcium, magnesium and phosphorus metabolism disorders
14.04.04      Bone metabolism disorders
14.04.04.002      Osteoporosis
15      Musculoskeletal and connective tissue disorders
15.02      Bone disorders (excl congenital and fractures)
15.02.03      Metabolic bone disorders
15.02.03.002      Osteoporosis
Description A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. [CTCAE] Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. [MeSH]
MedDRA Code 10031282
MeSH ID D010024
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Bone fragile | Disuse osteoporosis | Idiopathic osteoporosis | Osteoporosis | Osteoporosis NOS | Osteoporosis steroid-induced | Osteoporosis, unspecified | Other osteoporosis | Osteoporomalacia | Diffuse osteoporosis | Osteoporoses | Osteoporosis, Post-Traumatic | Osteoporosis, Post Traumatic | Post-Traumatic Osteoporoses | Post-Traumatic Osteoporosis | Osteoporosis, Senile | Osteoporoses, Senile | Senile Osteoporoses | Osteoporosis, Involutional | Senile Osteoporosis | Osteoporosis, Age-Related | Osteoporosis, Age Related | Bone Loss, Age-Related | Age-Related Bone Loss | Age-Related Bone Losses | Bone Loss, Age Related | Bone Losses, Age-Related | Age-Related Osteoporosis | Age Related Osteoporosis | Age-Related Osteoporoses | Osteoporoses, Age-Related
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01833Prednisolone sodium phosphate--
BADD_D01834Prednisone0.000276%
BADD_D01835Pregabalin--
BADD_D01903Raloxifene0.000498%
BADD_D01905Raltegravir0.004944%
BADD_D01906Raltegravir potassium--
BADD_D01925Rescinnamine--
BADD_D01942Riluzole--
BADD_D01950Risedronic acid--
BADD_D01951Risperidone0.000752%
BADD_D01952Ritonavir0.013222%
BADD_D01956Rivastigmine tartrate--
BADD_D01966Ropinirole--
BADD_D02002Selegiline--
BADD_D02016Sibutramine--
BADD_D02028Sirolimus--
BADD_D02029Sitagliptin0.000223%
BADD_D02047Sodium oxybate0.002253%
BADD_D02104Tacrine hydrochloride--
BADD_D02105Tacrolimus--
BADD_D02107Tafamidis0.000808%
BADD_D02112Tamoxifen citrate--
BADD_D02154Tenofovir0.288871%
BADD_D02170Testosterone--
BADD_D02174Testosterone undecanoate--
BADD_D02236Tofacitinib--
BADD_D02247Topiramate0.000126%
BADD_D02254Tramadol--
BADD_D02271Triamcinolone--
BADD_D02272Triamcinolone acetonide0.000068%
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ADReCS-Target
ADR Term Drug Name Target