Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Pathological fracture
ADR ID BADD_A03323
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.04      Bone and joint injuries
12.04.02      Fractures and dislocations NEC
12.04.02.006      Pathological fracture
15      Musculoskeletal and connective tissue disorders
15.08      Fractures
15.08.02      Fractures NEC
15.08.02.008      Pathological fracture
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.32      Neoplasm related morbidities
16.32.03      Oncologic complications and emergencies
16.32.03.007      Pathological fracture
Description Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed) [MeSH]
MedDRA Code 10034156
MeSH ID D005598
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Bone fracture spontaneous | Fracture pathological | Pathologic fracture of distal radius and ulna | Pathologic fracture of humerus | Pathologic fracture of neck of femur | Pathologic fracture of other specified part of femur | Pathologic fracture of other specified site | Pathologic fracture of tibia and fibula | Pathologic fracture of vertebrae | Pathologic fracture, unspecified site | Pathological fracture | Spontaneous bone fracture | Spontaneous fracture | Non-traumatic fracture | Pathological fracture of hip | Pathologic fracture of femur | Impending fracture | Fragility fracture | Pathologic fracture of rib | Fractures, Spontaneous | Fracture, Spontaneous | Spontaneous Fracture | Spontaneous Fractures | Fracture, Pathological | Fractures, Pathologic | Pathologic Fracture | Pathologic Fractures | Pathological Fractures | Fractures, Pathological | Fracture, Pathologic | Pathological Fracture
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01117Ibandronic acid0.001172%
BADD_D01213Isotretinoin--
BADD_D01242Lamivudine0.001518%
BADD_D01243Lamotrigine--
BADD_D01253Lenalidomide0.009138%
BADD_D01254Lenvatinib0.000280%
BADD_D01257Letrozole0.000843%
BADD_D01260Leuprolide acetate0.001434%
BADD_D01366Medroxyprogesterone acetate--
BADD_D01433Methylprednisolone--
BADD_D01434Methylprednisolone acetate--
BADD_D01436Methylprednisolone sodium succinate--
BADD_D01476Mirtazapine--
BADD_D01567Nilotinib0.000112%
BADD_D01646Oxycodone hydrochloride--
BADD_D01654Palbociclib0.000336%
BADD_D01662Pamidronic acid--
BADD_D01668Pantoprazole0.000016%
BADD_D01676Paricalcitol0.001962%
BADD_D01765Phenytoin--
BADD_D01771Pilocarpine hydrochloride--
BADD_D01798Pomalidomide0.001688%
BADD_D01831Prednisolone0.000122%
BADD_D01832Prednisolone acetate--
BADD_D01833Prednisolone sodium phosphate--
BADD_D01834Prednisone0.000022%
BADD_D01888Quetiapine--
BADD_D01889Quetiapine fumarate--
BADD_D01950Risedronic acid--
BADD_D01955Rivastigmine--
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