Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Renal tubular acidosis
ADR ID BADD_A03768
ADR Hierarchy
14      Metabolism and nutrition disorders
14.01      Acid-base disorders
14.01.01      Metabolic acidoses (excl diabetic acidoses)
14.01.01.005      Renal tubular acidosis
20      Renal and urinary disorders
20.05      Nephropathies
20.05.03      Nephropathies and tubular disorders NEC
20.05.03.003      Renal tubular acidosis
Description A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS. | The genetic defect is in the sodium bicarbonate cotransporter gene SLC4A4 resulting in impaired reabsorption of bicarbonate ions in the proximal renal tubules and bicarbonate-wasting. | The genetic defect is in the anion exchange protein gene SLC4A1 resulting in impaired excretion of hydrogen ions or renal acids in the distal renal tubules. [MeSH]
MedDRA Code 10038535
MeSH ID D000141
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acidosis renal tubular | Distal RTA | Primary RTA | Proximal renal tubular acidosis | Proximal RTA | Renal acidosis tubular | Renal tubular acidosis | Type 1 (distal) RTA | Type 2 (mixed) RTA | Type 2 (proximal) RTA | Type 4 (hyperkalemic) RTA | Type 4 (hyperkalaemic) RTA | Phosphate-losing tubular acidosis | Type 3 (combined proximal and distal) RTA | Distal renal tubular acidosis | Acidosis, Renal Tubular | Renal Tubular Acidosis | Renal Tubular Acidosis, Type II | Proximal Renal Tubular Acidosis | Type II Renal Tubular Acidosis | Renal Tubular Acidosis, Proximal | Renal Tubular Acidosis, Proximal, with Ocular Abnormalities | RTA, Proximal Type | Proximal Type RTA | Proximal Type RTAs | RTAs, Proximal Type | Acidosis, Renal Tubular, Type II | Renal Tubular Acidosis II | Renal Tubular Acidosis, Type I | Classic Distal Renal Tubular Acidosis | Distal Renal Tubular Acidosis | Renal Tubular Acidosis I | RTA, Gradient Type | Gradient Type RTA | Gradient Type RTAs | RTAs, Gradient Type | Type I Renal Tubular Acidosis | Autosomal Dominant Distal Renal Tubular Acidosis | Renal Tubular Acidosis 1 | RTA, Classic Type | Classic Type RTA | Classic Type RTAs | RTAs, Classic Type | RTA, Distal Type, Autosomal Dominant | Acidosis, Renal Tubular, Type I | Renal Tubular Acidosis, Distal, Autosomal Dominant
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D000032-phenylbutyric acid--
BADD_D00044Adefovir dipivoxil0.001270%
BADD_D00132Amphotericin b0.000188%
BADD_D00194Azacitidine0.000112%
BADD_D00344Canagliflozin0.000270%
BADD_D00349Capecitabine0.000224%
BADD_D00412Cephalexin0.000017%
BADD_D00594Deferasirox0.016109%
BADD_D00652Dichlorphenamide0.000115%
BADD_D00653Diclofenac0.000038%
BADD_D00765Empagliflozin0.000091%
BADD_D01120Ibuprofen0.000009%
BADD_D01133Ifosfamide--
BADD_D01194Irbesartan0.000378%
BADD_D01242Lamivudine0.001012%
BADD_D01265Levetiracetam0.000278%
BADD_D01285Levothyroxine0.000010%
BADD_D01300Lisinopril0.000032%
BADD_D01401Metformin0.000011%
BADD_D01633Oxaliplatin0.000168%
BADD_D01668Pantoprazole0.000033%
BADD_D01760Phenylbutyric acid--
BADD_D01804Posaconazole--
BADD_D02048Sodium phenylbutyrate--
BADD_D02073Streptozocin--
BADD_D02105Tacrolimus0.004456%
BADD_D02154Tenofovir0.014540%
BADD_D02247Topiramate0.001659%
BADD_D02392Zoledronic acid0.010020%
BADD_D02396Zonisamide--
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