Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Torsade de pointes
ADR ID BADD_A04352
ADR Hierarchy
02      Cardiac disorders
02.03      Cardiac arrhythmias
02.03.04      Ventricular arrhythmias and cardiac arrest
02.03.04.005      Torsade de pointes
Description A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION. [MeSH]
MedDRA Code 10044066
MeSH ID D016171
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Torsade de pointes | Torsades de pointes | TdP ventricular tachycardia | Helicoidal ventricular tachycardia | Torsades de Pointes | Pointes, Torsades de | de Pointes, Torsades | Torsade de Pointes | Pointes, Torsade de | de Pointes, Torsade
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01445Metoprolol0.000047%
BADD_D01449Metronidazole0.000026%
BADD_D01454Mianserin--
BADD_D01455Micafungin0.000150%
BADD_D01467Milrinone--
BADD_D01468Milrinone lactate--
BADD_D01476Mirtazapine0.000160%
BADD_D01477Misoprostol0.000617%
BADD_D01501Moxifloxacin--
BADD_D01502Moxifloxacin hydrochloride--
BADD_D01512Nadolol0.001206%
BADD_D01550Nelfinavir mesylate--
BADD_D01567Nilotinib--
BADD_D01587Norfloxacin--
BADD_D01588Nortriptyline--
BADD_D01598Ofloxacin--
BADD_D01599Olanzapine0.002421%
BADD_D01600Olanzapine pamoate--
BADD_D01617Ondansetron0.000032%
BADD_D01633Oxaliplatin--
BADD_D01656Paliperidone--
BADD_D01668Pantoprazole0.000065%
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01682Paroxetine impurity a--
BADD_D01687Pazopanib--
BADD_D01688Pazopanib hydrochloride--
BADD_D01717Pentamidine--
BADD_D01718Pentamidine isethionate--
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ADReCS-Target
ADR Term Drug Name Target