Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Cardiotoxicity
ADR ID BADD_A04698
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.007      Cardiotoxicity
02      Cardiac disorders
02.11      Cardiac disorders, signs and symptoms NEC
02.11.01      Cardiac disorders NEC
02.11.01.009      Cardiotoxicity
Description Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. [MeSH]
MedDRA Code 10048610
MeSH ID D066126
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cardiotoxicity | Acute cardiac toxicity | Cardiotoxicities | Cardiac Toxicity | Cardiac Toxicities | Toxicities, Cardiac | Toxicity, Cardiac
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.001835%
BADD_D00047Afatinib0.000112%
BADD_D00121Amlodipine0.000006%
BADD_D00142Anastrozole0.000318%
BADD_D00178Atenolol0.000116%
BADD_D00180Atomoxetine0.000232%
BADD_D00284Bortezomib0.000951%
BADD_D00286Bosutinib0.000168%
BADD_D00308Bupivacaine0.003126%
BADD_D00312Bupropion0.000451%
BADD_D00318Busulfan0.000168%
BADD_D00349Capecitabine0.002239%
BADD_D00364Carboplatin0.000336%
BADD_D00367Carfilzomib0.001287%
BADD_D00405Ceftriaxone0.006685%
BADD_D00417Cetirizine0.000029%
BADD_D00440Chloroquine0.000354%
BADD_D00474Cisplatin0.000560%
BADD_D00511Clozapine0.017732%
BADD_D00513Cobimetinib0.000112%
BADD_D00535Crizotinib0.000224%
BADD_D00545Cyclobenzaprine0.000016%
BADD_D00549Cyclophosphamide--
BADD_D00560Cytarabine0.000280%
BADD_D00561Cytarabine hydrochloride--
BADD_D00589Dasatinib0.000336%
BADD_D00590Daunorubicin--
BADD_D00592Daunorubicin hydrochloride--
BADD_D00623Dexamethasone0.000436%
BADD_D00633Dexrazoxane--
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ADReCS-Target
ADR Term Drug Name Target