Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Inappropriate antidiuretic hormone secretion
ADR ID BADD_A05243
ADR Hierarchy
05      Endocrine disorders
05.03      Hypothalamus and pituitary gland disorders
05.03.03      Posterior pituitary disorders
05.03.03.001      Inappropriate antidiuretic hormone secretion
14      Metabolism and nutrition disorders
14.05      Electrolyte and fluid balance conditions
14.05.07      Antidiuretic hormone related conditions
14.05.07.001      Inappropriate antidiuretic hormone secretion
Description A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced. [MeSH]
MedDRA Code 10053198
MeSH ID D007177
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
ADH inappropriate | ADH inappropriate secretion | Inapprop. ADH secretion syndrome | Inappropriate ADH | Inappropriate ADH secretion | Inappropriate vasopressin secretion | SIADH | Syndrome inappropriate ADH | Syndrome of inapp ADH secretion | Inappropriate antidiuretic hormone secretion | Schwartz-Bartter syndrome | Syndrome of inappropriate antidiuretic hormone secretion | Inappropriate ADH Syndrome | ADH Syndrome, Inappropriate | Syndrome, Inappropriate ADH | Syndrome of Inappropriate ADH (SIADH) Secretion | Schwartz-Bartter Syndrome | Schwartz Bartter Syndrome | Syndrome, Schwartz-Bartter | Antidiuretic Hormone, Inappropriate Secretion | Inappropriate Vasopressin Secretion Syndrome
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02294Trimipramine--
BADD_D02295Trimipramine maleate--
BADD_D02329Valproic acid0.000869%
BADD_D02331Valsartan0.000132%
BADD_D02346Venlafaxine0.000080%
BADD_D02347Venlafaxine hydrochloride--
BADD_D02358Vinblastine--
BADD_D02359Vinblastine sulfate--
BADD_D02360Vincristine0.000280%
BADD_D02362Vinflunine--
BADD_D02364Vinorelbine tartrate--
BADD_D02369Voriconazole0.029043%
BADD_D02371Vortioxetine0.003583%
BADD_D02394Zolpidem0.000051%
BADD_D02443Tiotropium0.000172%
BADD_D02456Vilazodone0.000319%
BADD_D02473Sodium chloride0.000531%
BADD_D02569Magnesium0.000294%
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