Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Precocious puberty
ADR ID BADD_A05552
ADR Hierarchy
05      Endocrine disorders
05.05      Endocrine disorders of gonadal function
05.05.03      Endocrine abnormalities of puberty
05.05.03.001      Precocious puberty
21      Reproductive system and breast disorders
21.03      Sexual function and fertility disorders
21.03.02      Sexual function and fertility disorders NEC
21.03.02.009      Precocious puberty
Description A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys. [CTCAE] Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. | An autosomal dominant hereditary disorder that is characterized by gonadotropin-dependent precocious puberty due to early activation of the hypothalamic-pituitary-gonadal axis. A mutation in the KISS1R gene has been identified. OMIM: 176400 | Familial precocious puberty in boys usually presents by age 4 with rapid VIRILIZATION and is also characterized by gonadotropin-independent testosterone secretion, low secretion of LUTEINIZING HORMONE, and advanced SPERMATOGENESIS in the testis. Mutations in the LHCGR gene have been identified. OMIM: 176410 [MeSH]
MedDRA Code 10058084
MeSH ID D011629
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Accelerated sexual maturation | Accelerated sexual maturity | Early puberty | Female sex maturation accelerated | Male sex maturation accelerated | Maturation sex accelerated | Precocious puberty NOS | Precocious sexual development and puberty, not elsewhere classified | Premature adrenarche | Premature thelarche | Puberty precocious | Sex maturation female accelerated | Sex maturation male accelerated | True precocious puberty | Precocious puberty | Premature pubarche | Central precocious puberty | Gonadotropin dependent precocious puberty | Puberty, Precocious | Precocious Puberties | Puberties, Precocious | Pubertas Praecox | Praecox, Pubertas | Precocious Puberty | Precocious Puberty, Central | Central Precocious Puberties | Central Precocious Puberty | Precocious Puberties, Central | Puberties, Central Precocious | Puberty, Central Precocious | Sexual Precocity | Precocities, Sexual | Precocity, Sexual | Sexual Precocities | Idiopathic Sexual Precocity | Idiopathic Sexual Precocities | Precocities, Idiopathic Sexual | Precocity, Idiopathic Sexual | Sexual Precocities, Idiopathic | Sexual Precocity, Idiopathic | Familial Precocious Puberty | Familial Precocious Puberties | Precocious Puberties, Familial | Precocious Puberty, Familial | Puberties, Familial Precocious | Puberty, Familial Precocious | Precocious Puberty, Male-Limited | Male-Limited Precocious Puberties | Male-Limited Precocious Puberty | Precocious Puberties, Male-Limited | Puberties, Male-Limited Precocious | Puberty, Male-Limited Precocious | Precocious Puberty, Male Limited | Testotoxicosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00107Aminoglutethimide--
BADD_D00318Busulfan0.000112%
BADD_D00501Clonazepam0.000065%
BADD_D00793Equilin sulfate--
BADD_D00912Fluconazole0.000090%
BADD_D01037Gonadotrophin chorionic--
BADD_D01243Lamotrigine0.000055%
BADD_D01260Leuprolide acetate--
BADD_D01261Leuprolide monoacetate--
BADD_D01317Loratadine0.000087%
BADD_D01431Methylphenidate0.000206%
BADD_D01530Nandrolone decanoate--
BADD_D01951Risperidone0.001515%
BADD_D02112Tamoxifen citrate--
BADD_D02170Testosterone0.000827%
BADD_D02172Testosterone enanthate--
BADD_D02173Testosterone propionate--
BADD_D02174Testosterone undecanoate--
BADD_D02329Valproic acid0.000100%
BADD_D02365Vismodegib0.000112%
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