| ADR Ontology |
| ADR Term |
Gene mutation |
| ADR ID |
BADD_A06250 |
| ADR Hierarchy |
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| Description |
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon. | A mutation that converts a sense codon (CODON) into a stop codon (CODON, TERMINATOR) or an unassigned codon and leads to the formation of truncated proteins. | A codon that is not assigned to an amino acid and is not a stop codon (CODON, TERMINATOR). Although they may lead to premature termination of translation, unassigned codons do not bind translation release factors (PEPTIDE TERMINATION FACTORS), as do stop codons. [MeSH] |
| MedDRA Code |
10064571 |
| MeSH ID |
D018389
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ADR Severity Grade (FAERS)
|
Not Available
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ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Gene genetic abnormality | Gene mutation | Nonsense mutation | Codon, Nonsense | Premature Termination Codon | Codon, Premature Termination | Codons, Premature Termination | Premature Termination Codons | Termination Codon, Premature | Termination Codons, Premature | Premature Stop Codon | Codon, Premature Stop | Codons, Premature Stop | Premature Stop Codons | Stop Codon, Premature | Stop Codons, Premature | Nonsense Codon | Codons, Nonsense | Nonsense Codons | Codon, Termination, Premature | Mutation, Nonsense | Mutations, Nonsense | Nonsense Mutations | Nonsense Mutation | Ochre Nonsense Codon | Codon, Ochre Nonsense | Codons, Ochre Nonsense | Nonsense Codon, Ochre | Nonsense Codons, Ochre | Ochre Nonsense Codons | Ochre Nonsense Mutation | Mutation, Ochre Nonsense | Mutations, Ochre Nonsense | Nonsense Mutation, Ochre | Nonsense Mutations, Ochre | Ochre Nonsense Mutations | Amber Nonsense Mutation | Amber Nonsense Mutations | Mutation, Amber Nonsense | Mutations, Amber Nonsense | Nonsense Mutation, Amber | Nonsense Mutations, Amber | Opal Nonsense Mutation | Mutation, Opal Nonsense | Mutations, Opal Nonsense | Nonsense Mutation, Opal | Nonsense Mutations, Opal | Opal Nonsense Mutations | Amber Nonsense Codon | Amber Nonsense Codons | Codon, Amber Nonsense | Codons, Amber Nonsense | Nonsense Codons, Amber | Nonsense Codon, Amber | Codon, Unassigned | Codons, Unassigned | Unassigned Codons | Unassigned Codon | Opal Nonsense Codon | Codon, Opal Nonsense | Codons, Opal Nonsense | Nonsense Codon, Opal | Nonsense Codons, Opal | Opal Nonsense Codons |
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| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D00549 | Cyclophosphamide | - | - | | BADD_D01004 | Ganciclovir sodium | - | - |
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