Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Osteonecrosis of jaw
ADR ID BADD_A06256
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.02      Bone disorders (excl congenital and fractures)
15.02.04      Bone disorders NEC
15.02.04.010      Osteonecrosis of jaw
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.05      Musculoskeletal necrosis and vascular insufficiency
24.04.05.005      Osteonecrosis of jaw
Description A disorder characterized by a necrotic process occurring in the bone of the mandible. [CTCAE] Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process. [MeSH]
MedDRA Code 10064658
MeSH ID D059266
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Aseptic necrosis of jaw | Osteonecrosis of jaw | Bisphosphonate-related osteonecrosis of the jaw | Medication-related osteonecrosis of jaw | Osteochemonecrosis of jaw | Bisphosphonate-Associated Osteonecrosis of the Jaw | Bisphosphonate Associated Osteonecrosis of the Jaw | Bisphosphonate-Induced Osteonecrosis of the Jaw | Bisphosphonate Induced Osteonecrosis of the Jaw | Bisphosphonate-Induced Osteonecrosis of the Jaws | Bisphosphonate Induced Osteonecrosis of the Jaws | Bisphosphonate-Related Osteonecrosis of the Jaw | Bisphosphonate Related Osteonecrosis of the Jaw | Osteonecrosis of the Jaws, Bisphosphonate-Associated | Osteonecrosis of the Jaws, Bisphosphonate Associated | Osteonecrosis of the Jaw, Bisphosphonate-Related | Osteonecrosis of the Jaw, Bisphosphonate Related | Osteonecrosis of the Jaws, Bisphosphonate-Induced | Osteonecrosis of the Jaws, Bisphosphonate Induced | Osteonecrosis of the Jaws, Bisphosphonate-Related | Osteonecrosis of the Jaws, Bisphosphonate Related | Osteonecrosis of the Jaw, Bisphosphonate-Associated | Osteonecrosis of the Jaw, Bisphosphonate Associated | Bisphosphonate-Associated Osteonecrosis of the Jaws | Bisphosphonate Associated Osteonecrosis of the Jaws | Osteonecrosis of the Jaw, Bisphosphonate-Induced | Osteonecrosis of the Jaw, Bisphosphonate Induced | Bisphosphonate-Associated Osteonecrosis | Bisphosphonate Associated Osteonecrosis | Bisphosphonate-Associated Osteonecroses | Osteonecroses, Bisphosphonate-Associated | Osteonecrosis, Bisphosphonate-Associated | Bisphosphonate Osteonecrosis | Bisphosphonate Osteonecroses | Osteonecroses, Bisphosphonate | Osteonecrosis, Bisphosphonate
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01103Hydroxychloroquine0.002789%
BADD_D01110Hydroxyurea0.000112%
BADD_D01116Ibandronate sodium--
BADD_D01117Ibandronic acid0.007602%
BADD_D01245Lansoprazole0.000199%
BADD_D01248Lapatinib0.000224%
BADD_D01253Lenalidomide--
BADD_D01254Lenvatinib0.001007%
BADD_D01257Letrozole0.004873%
BADD_D01376Melphalan0.000392%
BADD_D01433Methylprednisolone0.000080%
BADD_D01661Pamidronate disodium--
BADD_D01662Pamidronic acid0.002141%
BADD_D01687Pazopanib0.000560%
BADD_D01701Pemetrexed0.000112%
BADD_D01831Prednisolone0.001940%
BADD_D01834Prednisone0.000107%
BADD_D01903Raloxifene0.001357%
BADD_D01949Risedronate sodium--
BADD_D01950Risedronic acid--
BADD_D02026Simvastatin0.000025%
BADD_D02058Sorafenib0.000504%
BADD_D02100Sunitinib0.003750%
BADD_D02111Tamoxifen0.000238%
BADD_D02192Thalidomide0.000723%
BADD_D02250Toremifene citrate0.000667%
BADD_D02334Vandetanib0.000112%
BADD_D02363Vinorelbine0.000224%
BADD_D02392Zoledronic acid1.327249%
BADD_D02423Fondaparinux0.004934%
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