Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Toremifene citrate
Drug ID BADD_D02250
Description A first generation nonsteroidal selective estrogen receptor modulator (SERM) that is structurally related to tamoxifen. Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
Indications and Usage For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.
Marketing Status approved; investigational
ATC Code L02BA02
DrugBank ID DB00539
KEGG ID D00967
MeSH ID D017312
PubChem ID 3005572
TTD Drug ID D04VFJ
NDC Product Code 64980-404; 17337-0305; 90027-020; 73377-183; 72205-050; 52483-0060; 73309-291; 42747-327; 69539-152; 54893-0079
UNII 2498Y783QT
Synonyms Toremifene | Toremifene, (E)-Isomer | Toremifene Citrate | Citrate, Toremifene | Toremifene Citrate (1:1) | Fareston | FC-1157a | FC 1157a | FC1157a
Chemical Information
Molecular Formula C32H36ClNO8
CAS Registry Number 89778-27-8
SMILES CN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O) O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Arrhythmia02.03.02.001--Not Available
Arthritis15.01.01.001--
Aspartate aminotransferase13.03.04.008--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Back pain15.03.04.005--
Blood alkaline phosphatase13.04.02.010--Not Available
Blood bilirubin13.03.04.015--Not Available
Cardiac failure02.05.01.001--
Cataract06.06.01.001--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Corneal opacity06.06.03.005--Not Available
Cyst08.03.05.001; 16.02.02.002--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry eye06.08.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Ear disorder04.03.01.001--Not Available
Endometrial adenocarcinoma21.07.02.011; 16.12.02.0030.000334%Not Available
Endometrial cancer16.12.02.001; 21.07.02.002--Not Available
Endometrial hyperplasia21.07.01.002--Not Available
Endometrial hypertrophy21.07.01.003--Not Available
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