Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hypoxic-ischaemic encephalopathy
ADR ID BADD_A06611
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.006      Hypoxic-ischaemic encephalopathy
22      Respiratory, thoracic and mediastinal disorders
22.02      Respiratory disorders NEC
22.02.02      Conditions associated with abnormal gas exchange
22.02.02.011      Hypoxic-ischaemic encephalopathy
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.06      Cerebrovascular and spinal necrosis and vascular insufficiency
24.04.06.021      Hypoxic-ischaemic encephalopathy
Description A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives. [MeSH]
MedDRA Code 10070511
MeSH ID D002534; D020925; D002545
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Encephalopathy pulmonary | Hypoxic encephalopathy | Hypercapnic encephalopathy | Anoxic encephalopathy | Hypoxic-ischaemic encephalopathy | Hypoxic-ischemic encephalopathy | Ischemic encephalopathy | Ischaemic encephalopathy | Hypoxia, Brain | Cerebral Hypoxia | Hypoxia, Cerebral | Brain Hypoxia | Anoxic Brain Damage | Brain Damage, Anoxic | Damage, Anoxic Brain | Anoxic Encephalopathy | Anoxic Encephalopathies | Encephalopathies, Anoxic | Encephalopathy, Anoxic | Hypoxic Brain Damage | Brain Damage, Hypoxic | Damage, Hypoxic Brain | Hypoxic Encephalopathy | Encephalopathy, Hypoxic | Encephalopathies, Hypoxic | Hypoxic Encephalopathies | Anoxia, Brain | Cerebral Anoxia | Anoxia, Cerebral | Brain Anoxia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00085Alprazolam0.000058%
BADD_D00115Amiodarone0.000135%
BADD_D00129Amoxicillin0.000007%
BADD_D00130Amphetamine0.000080%
BADD_D00161Argatroban0.000082%
BADD_D00165Aripiprazole0.000119%
BADD_D00169Arsenic trioxide0.000112%
BADD_D00187Atracurium--
BADD_D00209Baclofen0.000348%
BADD_D00285Bosentan0.000301%
BADD_D00304Bromocriptine0.001319%
BADD_D00310Buprenorphine0.000362%
BADD_D00312Bupropion0.000092%
BADD_D00356Carbamazepine0.000186%
BADD_D00364Carboplatin0.000392%
BADD_D00405Ceftriaxone0.004457%
BADD_D00410Celecoxib0.000050%
BADD_D00504Clopidogrel0.000021%
BADD_D00563Dabigatran0.000489%
BADD_D00623Dexamethasone0.000509%
BADD_D00648Diazepam0.000201%
BADD_D00653Diclofenac0.000026%
BADD_D00684Dinoprostone0.000061%
BADD_D00686Diphenhydramine0.000873%
BADD_D00782Epinephrine0.000081%
BADD_D00879Fentanyl0.000317%
BADD_D00890Ferumoxytol non-stoichiometric magnetite-
BADD_D00926Fluorescein0.000107%
BADD_D00932Fluoxetine0.000039%
BADD_D00979Furosemide0.000035%
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