Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ferumoxytol non-stoichiometric magnetite
Drug ID BADD_D00890
Description Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) [A32478]. It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral pH solution that may be administered at relatively high dose by rapid intravenous injection [L2181].
Indications and Usage This drug is indicated for the treatment of iron deficiency anemia in adult patients who have experienced intolerance to oral iron or have experienced an unsatisfactory response to oral iron or who have chronic kidney disease (CKD) [FDA label].
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB06215
KEGG ID D04177; D09142
MeSH ID D052203
PubChem ID 6432052
TTD Drug ID D06CTM
NDC Product Code 63552-026
UNII CLH5FT6412
Synonyms Ferrosoferric Oxide | Oxide, Ferrosoferric | Ferriferrous Oxide | Oxide, Ferriferrous | Magnetite | Feraheme | Ferumoxytol
Chemical Information
Molecular Formula Fe3O4
CAS Registry Number 119683-68-0
SMILES [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002-
Abdominal pain upper07.01.05.003-
Acute myocardial infarction24.04.04.001; 02.02.02.001-Not Available
Agitation19.06.02.001; 17.02.05.012-
Anaphylactic reaction10.01.07.001; 24.06.03.006-
Anaphylactic shock24.06.02.004; 10.01.07.002-Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003-Not Available
Anxiety19.06.02.002-
Aphasia19.21.01.001; 17.02.03.001-
Apnoea22.02.01.001-
Arthralgia15.01.02.001-
Back pain15.03.04.005-
Bronchospasm22.03.01.004; 10.01.03.012-
Burning sensation17.02.06.001; 08.01.09.029-Not Available
Cardiac arrest02.03.04.001-
Cardio-respiratory arrest22.02.06.007; 02.03.04.002-Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009-Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011-Not Available
Chills15.05.03.016; 08.01.09.001-
Constipation07.02.02.001--
Cough22.02.03.001-
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005-Not Available
Cyanosis22.02.02.007; 23.06.04.005; 02.11.04.004; 24.03.01.007-
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003-
Dyskinesia17.01.02.006-
Dyspnoea02.11.05.003; 22.02.01.004-
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.002--Not Available
Erythema23.03.06.001-Not Available
Extravasation08.01.03.008-Not Available
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