Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00008Abacavir0.004121%
BADD_D00014Abiraterone0.003904%
BADD_D00018Acarbose0.001625%
BADD_D00023Acetaminophen0.000125%
BADD_D00032Acetylcysteine0.000149%
BADD_D00033Acetylsalicylic acid0.000077%
BADD_D00036Acitretin0.001875%
BADD_D00039Acyclovir0.000285%
BADD_D00044Adefovir dipivoxil0.000423%
BADD_D00052Albendazole0.009298%
BADD_D00079Alogliptin0.000798%
BADD_D00086Alprostadil0.001148%
BADD_D00115Amiodarone0.001751%
BADD_D00121Amlodipine0.000022%
BADD_D00129Amoxicillin0.000135%
BADD_D00132Amphotericin b0.000301%
BADD_D00142Anastrozole0.001271%
BADD_D00176Atazanavir0.001203%
BADD_D00178Atenolol0.000058%
BADD_D00180Atomoxetine0.000348%
BADD_D00186Atovaquone0.000213%
BADD_D00193Axitinib--
BADD_D00195Azathioprine0.002350%
BADD_D00203Azithromycin0.000028%
BADD_D00206Aztreonam0.000049%
BADD_D00221Bedaquiline0.001027%
BADD_D00271Bicalutamide0.005202%
BADD_D00286Bosutinib0.000728%
BADD_D00308Bupivacaine0.000714%
BADD_D00312Bupropion0.000092%
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