Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00932Fluoxetine0.000285%
BADD_D00948Fluvastatin0.002853%
BADD_D00978Fulvestrant--
BADD_D00981Gabapentin0.000298%
BADD_D00982Gabapentin enacarbil-
BADD_D01008Gefitinib0.000504%
BADD_D01012Gemfibrozil0.000451%
BADD_D01023Glimepiride0.000085%
BADD_D01038Goserelin0.000667%
BADD_D01073Histrelin--
BADD_D01081Hydralazine0.000982%
BADD_D01083Hydrochlorothiazide0.000040%
BADD_D01103Hydroxychloroquine0.003719%
BADD_D01120Ibuprofen0.000009%
BADD_D01156Indomethacin--
BADD_D01194Irbesartan0.000441%
BADD_D01204Isoniazid0.139822%
BADD_D01217Itraconazole0.029395%
BADD_D01220Ivacaftor-
BADD_D01228Ketamine0.000179%
BADD_D01230Ketoconazole0.000099%
BADD_D01231Ketoprofen0.005601%
BADD_D01236Labetalol0.000569%
BADD_D01242Lamivudine0.006071%
BADD_D01243Lamotrigine0.002814%
BADD_D01245Lansoprazole0.001064%
BADD_D01252Leflunomide0.006641%
BADD_D01254Lenvatinib0.000616%
BADD_D01257Letrozole0.001844%
BADD_D01265Levetiracetam0.001510%
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