Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01864Propofol0.000536%
BADD_D01869Propylthiouracil0.014106%
BADD_D01888Quetiapine0.000600%
BADD_D01898Rabeprazole0.000911%
BADD_D01905Raltegravir0.011537%
BADD_D01909Ramipril0.000839%
BADD_D01922Regorafenib0.000862%
BADD_D01924Repaglinide0.001113%
BADD_D01933Ribavirin0.041536%
BADD_D01936Rifampicin0.006906%
BADD_D01942Riluzole0.000538%
BADD_D01951Risperidone0.002485%
BADD_D01952Ritonavir0.001102%
BADD_D01957Rizatriptan0.000136%
BADD_D01971Rosuvastatin0.000837%
BADD_D01973Rotigotine0.000367%
BADD_D01992Saxagliptin0.000327%
BADD_D02010Sertraline0.000162%
BADD_D02026Simvastatin0.000252%
BADD_D02053Sofosbuvir0.001835%
BADD_D02058Sorafenib--
BADD_D02066Spironolactone0.000128%
BADD_D02093Sulfasalazine0.001424%
BADD_D02106Tadalafil0.000781%
BADD_D02147Telmisartan0.001041%
BADD_D02150Temozolomide0.000772%
BADD_D02154Tenofovir0.010663%
BADD_D02160Terbinafine0.003783%
BADD_D02217Tigecycline0.000122%
BADD_D02230Tizanidine0.000167%
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