Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Small fibre neuropathy
ADR ID BADD_A09221
ADR Hierarchy
05      Endocrine disorders
05.07      Diabetic complications
05.07.04      Diabetic complications neurological
05.07.04.007      Small fibre neuropathy
14      Metabolism and nutrition disorders
14.07      Diabetic complications
14.07.04      Diabetic complications neurological
14.07.04.007      Small fibre neuropathy
17      Nervous system disorders
17.09      Peripheral neuropathies
17.09.03      Peripheral neuropathies NEC
17.09.03.021      Small fibre neuropathy
Description Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (see A FIBERS) and unmyelinated C FIBERS. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweating or facial flushing). Small fiber neuropathy can be idiopathic or associated with underlying diseases (e.g., AMYLOIDOSIS; DIABETES MELLITUS; SARCOIDOSIS; or VASCULITIS). [MeSH]
MedDRA Code 10073928
MeSH ID D000071075
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Small fibre neuropathy | Small fiber neuropathy | Small Fiber Neuropathy | Neuropathies, Small Fiber | Neuropathy, Small Fiber | Small Fiber Neuropathies | Small Nerve Fiber Neuropathy | Small Fibre Neuropathy | Neuropathies, Small Fibre | Neuropathy, Small Fibre | Small Fibre Neuropathies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00693Disopyramide0.001911%
BADD_D01275Levofloxacin0.000042%
BADD_D01418Methotrexate0.000114%
BADD_D01576Nitrofurantoin--
BADD_D02015Sevoflurane0.000268%
BADD_D02160Terbinafine0.000223%
BADD_D02165Teriflunomide0.000940%
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