Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disopyramide
Drug ID BADD_D00693
Description A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Indications and Usage For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Marketing Status approved
ATC Code C01BA03
DrugBank ID DB00280
KEGG ID D00303
MeSH ID D004206
PubChem ID 3114
TTD Drug ID D0M4YC
NDC Product Code Not Available
UNII GFO928U8MQ
Synonyms Disopyramide | Diisopyramide | Disopyramide Phosphate | Disopyramide Phosphate (1:1) | Disopyramide Phosphate (1:1), (+-)-Isomer | Disopyramide Phosphate (1:1), (R)-Isomer | Disopyramide Phosphate (1:1), (S)-Isomer | Disopyramide, (+-)-Isomer | Disopyramide, (R)-Isomer | Disopyramide, (S)-Isomer | Disopyramide, D-Tartrate (1:1), (S)-Isomer | Disopyramide, L-Tartrate (1:1), (R)-Isomer | Disopyramide, L-Tartrate (1:1), (S)-Isomer | Disopyramide, L-Tartrate (1:2), (+-)-Isomer | Disopyramide, L-Tartrate, (S)-isomer | Norpace | Palpitin | Palpitine | Rhythmodan | Ritmilen | Rythmilen | SC-13957 | SC 13957 | SC13957 | Disopyramide Monohydrochloride
Chemical Information
Molecular Formula C21H29N3O
CAS Registry Number 3737-09-5
SMILES CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain upper07.01.05.003--
Accommodation disorder06.02.04.001--Not Available
Acute psychosis19.03.01.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Apnoea22.02.01.001--
Arrhythmia02.03.02.0010.001911%Not Available
Asthenia08.01.01.0010.004204%Not Available
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002--Not Available
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.002866%Not Available
Bundle branch block02.03.01.009--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.0020.001911%Not Available
Cardiac output decreased13.14.02.001--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.001911%
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.002--Not Available
Coma17.02.09.001--Not Available
Condition aggravated08.01.03.004--Not Available
Confusional state19.13.01.001; 17.02.03.0050.001911%
Constipation07.02.02.001--
Cyanosis23.06.04.005; 02.11.04.004; 24.03.01.007; 22.02.02.007--
Defect conduction intraventricular02.03.01.018--Not Available
Depression19.15.01.001--
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ADReCS-Target
Drug Name ADR Term Target
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