Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Acyclovir
Drug ID BADD_D00039
Description Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.[L7321] Acyclovir was granted FDA approval on 29 March 1982.[L7318]
Indications and Usage An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older.[L7303] Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox.[L7315] An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients.[L7318] An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older.[L7321] An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis.[L7324] An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.[L7327]
Marketing Status approved
ATC Code S01AD03; J05AB01; D06BB03
DrugBank ID DB00787
KEGG ID D00222
MeSH ID D000212
PubChem ID 135398513
TTD Drug ID D0B5MP
NDC Product Code 80425-0270; 51927-0192; 52935-0015; 65977-0058; 16714-885; 0093-3630; 23155-227; 31722-681; 0187-0994; 50090-0645; 50268-061; 51407-146; 51672-1360; 53002-0082; 60505-5307; 63187-366; 65162-835; 67296-1495; 67296-1707; 68071-2811; 68084-108; 0472-0082; 69367-138; 70518-2085; 70934-354; 71205-056; 71335-0470; 71335-1222; 71335-9620; 75834-122; 52423-0906; 23155-228; 31722-777; 35356-903; 43063-826; 0143-9658; 51407-145; 53002-0270; 54348-627; 60505-0042; 61442-113; 63187-253; 67296-1185; 67296-1543; 68382-049; 68788-7895; 69076-146; 69452-290; 70771-1081; 71209-006; 71335-0323; 72241-026; 81288-019; 46014-1017; 43063-928; 45802-044; 51655-965; 55700-539; 61442-112; 61919-003; 62135-019; 62135-039; 63187-182; 63187-574; 65841-803; 67296-1034; 67296-1300; 68071-2235; 68071-2526; 68382-126; 68788-8203; 68788-8247; 69452-291; 70934-800; 70934-828; 71205-209; 71209-005; 71335-1757; 62332-248; 65841-829; 68071-2247; 69117-0019; 70518-3306; 70771-1808; 71335-1053; 72241-027; 75834-123; 81288-018; 81288-039; 38779-0173; 76003-0010; 0187-0993; 50090-0638; 50090-1624; 53002-0272; 59651-493; 60760-606; 61442-114; 63187-154; 67296-1089; 68071-2299; 68071-2854; 68084-107; 70518-0427; 70518-2496; 70518-3331; 70934-132; 70934-907; 70954-188; 71335-1013; 72888-079; 75834-124; 65085-0039; 50383-810; 51655-679; 58118-0791; 0378-8700; 66689-342; 68084-109; 68788-8434; 69117-0018; 70518-1332; 70518-2455; 70518-2518; 72162-1735; 72189-232; 72578-101; 76420-050; 17337-0005; 43063-589; 50090-3250; 53002-0083; 53002-2450; 60760-652; 61919-530; 63629-1678; 63629-2327; 65841-802; 67296-1108; 68382-792; 68788-7575; 69117-0039; 70518-3436; 70771-1082; 70771-1383; 71205-243; 71205-472; 71335-9721; 72162-1908; 72578-002; 0904-5789; 62991-1004; 69132-001; 50090-0644; 50090-1567; 51655-300; 55700-835; 61919-370; 63187-192; 63629-9174; 65162-836; 67296-2040; 68462-746; 68788-7760; 69367-137; 70518-2117; 70771-1371; 70771-1384; 71205-371; 71209-004; 71335-0695; 72162-1704; 0904-5790; 69988-0027; 13668-515; 17856-0083; 31722-778; 0168-0825; 51079-550; 55154-7629; 60505-5306; 63629-2009; 63629-2328; 67296-1193; 67296-1458; 68071-2279; 68071-2287; 68071-3222; 68382-048; 68382-125; 69097-656; 70934-984; 71205-388; 71205-578; 71335-0280; 71335-1381; 71335-1645; 72578-082; 76483-047; 12711-9744; 17337-0041; 49452-0001; 51552-0671; 51927-2994; 53069-0120; 63310-2090; 23155-229; 23155-485; 42291-017; 43547-499; 50268-062; 54348-624; 55154-4332; 68382-791; 68788-7923; 70700-107; 71205-053; 71205-391; 0591-1159; 71335-1290; 71403-049; 72162-1724; 72241-028; 0713-0630; 76483-042; 12711-9755; 49711-0094; 65015-600; 33342-439; 0143-9657; 50090-5610; 50090-6335; 53002-0271
UNII X4HES1O11F
Synonyms Acyclovir | 9-((2-Hydroxyethoxy)methyl)guanine | Aciclovir | Acycloguanosine | Herpoviric | Aciclobeta | Aciclostad | Isavir | Laciken | Mapox | Maynar | Milavir | Opthavir | Supraviran | Viclovir | Vipral | Virax-Puren | Virax Puren | ViraxPuren | Virherpes | Virmen | Virolex | Virupos | Virzin | Wellcome-248U | Wellcome 248U | Wellcome248U | Zoliparin | Zovirax | Zyclir | Aciclovir Alonga | Alonga, Aciclovir | Acifur | Acipen Solutab | Solutab, Acipen | Acivir | Activir | Acyclo-V | Acyclo V | Acyclovir Sodium | Sodium, Acyclovir | Antiherpes Creme | aciclovir von ct | Avirax | Cicloferon | Clonorax | Cusiviral | Genvir | Herpetad | Herpofug | Herpotern | Aci-Sanorania | Aci Sanorania | Aciclovir-Sanorania | Aciclovir Sanorania | Acic
Chemical Information
Molecular Formula C8H11N5O3
CAS Registry Number 59277-89-3
SMILES C1=NC2=C(N1COCCO)N=C(NC2=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Stupor19.02.05.004; 17.02.04.007--Not Available
Swelling08.01.03.015--Not Available
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.0180.000406%Not Available
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.000107%Not Available
Tachycardia02.03.02.0070.000299%Not Available
Tenderness08.01.08.005--Not Available
Therapeutic response decreased08.06.01.0160.000107%Not Available
Therapeutic response unexpected08.06.01.0010.000349%Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Throat irritation07.05.05.037; 22.12.03.0290.000071%Not Available
Thrombocytopenia01.08.01.0020.000356%Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Thrombocytosis01.08.02.001--Not Available
Thrombotic microangiopathy24.01.01.013; 20.01.07.004; 01.01.02.0060.000071%Not Available
Thrombotic thrombocytopenic purpura23.06.01.011; 01.08.01.005; 24.07.06.0140.000071%
Tinnitus17.04.07.004; 04.04.01.0020.000107%
Toxic encephalopathy17.13.01.004; 12.03.01.0270.002174%Not Available
Toxic epidermal necrolysis11.07.01.006; 10.01.01.006; 23.03.01.008; 12.03.01.0150.000249%
Transient ischaemic attack24.04.06.005; 17.08.04.0010.000143%
Tremor17.01.06.0020.000706%
Trigeminal neuralgia17.04.08.0010.000071%Not Available
Trismus17.01.03.004; 15.05.04.0040.000071%
Type I hypersensitivity10.01.03.006--Not Available
Unresponsive to stimuli17.02.05.0310.000107%Not Available
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.0110.000891%
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.0010.000941%
Uveitis06.04.03.003; 10.02.01.023--
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