Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Alprazolam
Drug ID BADD_D00085
Description Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.[A18125] Alprazolam's adverse effects are generally related to the sedation it can cause.[A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death.[A18125] Alprazolam was given FDA approval on October 16, 1981.[L6148]
Indications and Usage Alprazolam is indicated for the acute treatment of generalized anxiety disorder in adults.[L34783] Alprazolam is also indicated, either as a standard or extended-release formulation, for the treatment of panic disorder with or without agoraphobia in adults.[L34783, L34788] Alprazolam may also be prescribed off-label for insomnia, premenstrual syndrome, and depression.[A177973]
Marketing Status approved; illicit; investigational
ATC Code N05BA12
DrugBank ID DB00404
KEGG ID D00225
MeSH ID D000525
PubChem ID 2118
TTD Drug ID D0L9GG
NDC Product Code 72789-151; 49452-0295; 0009-0055; 45865-972; 49884-213; 0228-2039; 0228-3084; 53002-3952; 59762-3719; 60760-550; 63187-966; 68071-2220; 68071-5243; 68788-7595; 70518-2870; 70518-3763; 71335-1386; 71335-1669; 71335-9666; 71335-9667; 71610-696; 72189-213; 0228-2031; 65862-678; 49884-110; 51991-706; 0228-3086; 53002-0340; 59762-0066; 59762-3722; 60760-678; 65862-677; 67296-1748; 68071-2976; 68788-7596; 0054-3068; 71205-652; 71335-0849; 71335-1576; 71335-1839; 72189-240; 72789-313; 0781-1079; 80425-0110; 42816-0055; 42816-0094; 65862-454; 65862-457; 71554-013; 59762-0057; 61919-005; 63187-444; 63187-445; 63187-916; 65162-813; 68071-2965; 71205-284; 71205-718; 71335-1907; 65162-810; 71335-1291; 71610-112; 0615-8295; 0228-2029; 12780-4630; 64330-013; 0009-0068; 49884-214; 50090-2819; 50090-5258; 0228-2027; 51991-705; 51991-707; 59762-3721; 65862-676; 67296-0757; 67544-414; 68071-2236; 68071-2794; 70518-3259; 70954-510; 71205-614; 71335-1894; 72189-121; 72189-450; 0781-1061; 12828-0040; 42816-0029; 42816-0057; 0009-0057; 0009-0059; 43063-609; 45865-424; 50090-5262; 0228-4019; 0228-4022; 55700-929; 59762-0059; 59762-3720; 63187-443; 65862-456; 68071-2292; 68071-4831; 70954-509; 70954-511; 71205-227; 71335-1477; 80425-0161; 0009-5144; 42816-0090; 65015-634; 65862-679; 0009-0066; 50090-5078; 51991-704; 0228-3083; 67544-415; 68071-5263; 68788-8410; 70518-2785; 70518-3730; 0781-1077; 80425-0099; 80425-0100; 80425-0284; 42816-0059; 42816-0066; 42816-0068; 63187-518; 68071-5113; 68071-5128; 68788-7613; 68788-9682; 71335-1092; 71610-113; 72789-042; 83008-010; 65862-455; 0009-0029; 0009-0090; 45865-993; 49884-111; 0228-4024; 63187-971; 65162-809; 65162-812; 68788-7594; 68788-8394; 71335-2133; 71335-9660; 49999-252; 50090-2896; 50090-5261; 63187-225; 67544-347; 68071-2966; 68788-8414; 70954-508; 71335-0427; 71335-0920; 71335-1129; 72162-1059; 72789-024; 72789-328; 0781-1089; 57218-312; 0009-0094; 0228-3087; 0228-4025; 53002-4181; 55289-523; 59762-0068
UNII YU55MQ3IZY
Synonyms Alprazolam | Alprazolan | Trankimazin | U-31,889 | U31,889 | Xanax | Alprox | Esparon | Cassadan | D-65MT | D65MT | Kalma | Novo-Alprazol | Novo Alprazol | Nu-Alpraz | Nu Alpraz | Ralozam | Tafil | Apo-Alpraz | Apo Alpraz
Chemical Information
Molecular Formula C17H13ClN4
CAS Registry Number 28981-97-7
SMILES CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Psychiatric symptom19.01.02.0010.000052%Not Available
Respiratory disorder neonatal18.04.09.002; 22.11.01.0020.000019%Not Available
Ill-defined disorder08.01.03.049--Not Available
Intervertebral disc disorder15.10.01.0030.000029%Not Available
Inner ear disorder04.04.02.002--Not Available
Cardiac fibrillation02.03.02.0210.000019%Not Available
Adjustment disorder19.23.01.0010.000019%Not Available
Disease recurrence08.01.03.0500.000140%Not Available
Dyssomnia19.02.05.006; 17.15.04.0040.000019%Not Available
Psychotic disorder19.03.01.0020.000227%
Hepatobiliary disease09.01.08.003--Not Available
Sinus disorder22.04.06.0020.000085%
Poor quality sleep17.15.04.002; 19.02.05.0050.000085%Not Available
Suicidal behaviour19.12.01.0060.000058%Not Available
Cardiovascular insufficiency02.11.01.011; 24.06.03.0050.000019%Not Available
Substance abuse19.07.06.0180.000654%Not Available
Psychiatric decompensation19.01.02.0100.000029%Not Available
Oromandibular dystonia17.01.03.0060.000019%Not Available
Brain injury19.07.03.007; 17.11.01.0030.000039%Not Available
Cholestatic liver injury09.01.07.0160.000029%Not Available
Intellectual disability19.21.06.001; 17.03.07.001--Not Available
Hypertransaminasaemia09.01.02.0050.000078%Not Available
Neurological decompensation17.02.05.0300.000107%Not Available
Acute kidney injury20.01.03.0160.000612%
Hypoxic-ischaemic encephalopathy22.02.02.011; 17.13.02.006; 24.04.06.0210.000058%Not Available
Slow speech17.02.08.016; 19.19.02.0040.000091%Not Available
Glassy eyes08.01.03.055; 06.08.03.0210.000043%Not Available
Muscle tone disorder17.05.02.014; 15.05.04.017--Not Available
Foetal heart rate deceleration abnormality18.03.02.012; 02.03.02.0220.000019%Not Available
Irregular breathing22.02.01.0260.000019%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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