Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Alprazolam
Drug ID BADD_D00085
Description Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.[A18125] Alprazolam's adverse effects are generally related to the sedation it can cause.[A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death.[A18125] Alprazolam was given FDA approval on October 16, 1981.[L6148]
Indications and Usage Alprazolam is indicated for the acute treatment of generalized anxiety disorder in adults.[L34783] Alprazolam is also indicated, either as a standard or extended-release formulation, for the treatment of panic disorder with or without agoraphobia in adults.[L34783, L34788] Alprazolam may also be prescribed off-label for insomnia, premenstrual syndrome, and depression.[A177973]
Marketing Status approved; illicit; investigational
ATC Code N05BA12
DrugBank ID DB00404
KEGG ID D00225
MeSH ID D000525
PubChem ID 2118
TTD Drug ID D0L9GG
NDC Product Code 72789-151; 49452-0295; 0009-0055; 45865-972; 49884-213; 0228-2039; 0228-3084; 53002-3952; 59762-3719; 60760-550; 63187-966; 68071-2220; 68071-5243; 68788-7595; 70518-2870; 70518-3763; 71335-1386; 71335-1669; 71335-9666; 71335-9667; 71610-696; 72189-213; 0228-2031; 65862-678; 49884-110; 51991-706; 0228-3086; 53002-0340; 59762-0066; 59762-3722; 60760-678; 65862-677; 67296-1748; 68071-2976; 68788-7596; 0054-3068; 71205-652; 71335-0849; 71335-1576; 71335-1839; 72189-240; 72789-313; 0781-1079; 80425-0110; 42816-0055; 42816-0094; 65862-454; 65862-457; 71554-013; 59762-0057; 61919-005; 63187-444; 63187-445; 63187-916; 65162-813; 68071-2965; 71205-284; 71205-718; 71335-1907; 65162-810; 71335-1291; 71610-112; 0615-8295; 0228-2029; 12780-4630; 64330-013; 0009-0068; 49884-214; 50090-2819; 50090-5258; 0228-2027; 51991-705; 51991-707; 59762-3721; 65862-676; 67296-0757; 67544-414; 68071-2236; 68071-2794; 70518-3259; 70954-510; 71205-614; 71335-1894; 72189-121; 72189-450; 0781-1061; 12828-0040; 42816-0029; 42816-0057; 0009-0057; 0009-0059; 43063-609; 45865-424; 50090-5262; 0228-4019; 0228-4022; 55700-929; 59762-0059; 59762-3720; 63187-443; 65862-456; 68071-2292; 68071-4831; 70954-509; 70954-511; 71205-227; 71335-1477; 80425-0161; 0009-5144; 42816-0090; 65015-634; 65862-679; 0009-0066; 50090-5078; 51991-704; 0228-3083; 67544-415; 68071-5263; 68788-8410; 70518-2785; 70518-3730; 0781-1077; 80425-0099; 80425-0100; 80425-0284; 42816-0059; 42816-0066; 42816-0068; 63187-518; 68071-5113; 68071-5128; 68788-7613; 68788-9682; 71335-1092; 71610-113; 72789-042; 83008-010; 65862-455; 0009-0029; 0009-0090; 45865-993; 49884-111; 0228-4024; 63187-971; 65162-809; 65162-812; 68788-7594; 68788-8394; 71335-2133; 71335-9660; 49999-252; 50090-2896; 50090-5261; 63187-225; 67544-347; 68071-2966; 68788-8414; 70954-508; 71335-0427; 71335-0920; 71335-1129; 72162-1059; 72789-024; 72789-328; 0781-1089; 57218-312; 0009-0094; 0228-3087; 0228-4025; 53002-4181; 55289-523; 59762-0068
UNII YU55MQ3IZY
Synonyms Alprazolam | Alprazolan | Trankimazin | U-31,889 | U31,889 | Xanax | Alprox | Esparon | Cassadan | D-65MT | D65MT | Kalma | Novo-Alprazol | Novo Alprazol | Nu-Alpraz | Nu Alpraz | Ralozam | Tafil | Apo-Alpraz | Apo Alpraz
Chemical Information
Molecular Formula C17H13ClN4
CAS Registry Number 28981-97-7
SMILES CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Negative thoughts19.15.02.0120.000019%Not Available
Sopor19.02.04.002; 17.02.04.0210.005828%Not Available
Foot deformity15.10.03.0050.000019%Not Available
Vagus nerve disorder17.04.06.0040.000029%
Foaming at mouth17.02.05.056; 07.05.05.019; 08.01.03.0700.000019%Not Available
Neurodevelopmental disorder17.02.10.031; 19.22.02.0030.000019%Not Available
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000068%Not Available
Acute lung injury22.01.03.0100.000019%Not Available
Hyporesponsive to stimuli17.02.05.0570.000058%Not Available
Neonatal behavioural syndrome22.11.02.007; 18.04.04.010; 17.02.05.058; 15.05.04.0200.000029%Not Available
Disorganised speech19.19.02.005; 17.02.08.0170.000019%Not Available
Infantile apnoea22.11.02.004; 18.04.15.0030.000019%Not Available
Selective eating disorder14.03.02.024; 19.09.01.0120.000019%Not Available
Acquired amegakaryocytic thrombocytopenia10.02.01.066; 01.08.01.0110.000019%Not Available
Allergic reaction to excipient10.01.01.0350.000066%Not Available
Anamnestic reaction10.02.01.0680.000039%Not Available
Behaviour disorder19.01.01.0050.000146%Not Available
Cardio-respiratory arrest neonatal22.11.02.013; 18.04.17.004; 02.03.04.0230.000019%Not Available
Coronary no-reflow phenomenon24.04.04.030; 02.02.02.0250.000029%Not Available
Dilated cardiomyopathy02.04.01.0170.000029%Not Available
Drug ineffective for unapproved indication08.06.01.038; 12.09.02.0020.000392%Not Available
Drug use disorder19.07.06.0120.001378%Not Available
Glossopharyngeal nerve disorder17.04.11.0010.000029%
Hepatic cytolysis09.01.07.0360.000078%Not Available
Illness08.01.03.091--Not Available
Illogical thinking19.10.03.0120.000029%Not Available
Lung opacity22.12.01.0060.000029%Not Available
Mixed anxiety and depressive disorder19.15.01.0100.000029%Not Available
Myocardial injury02.04.02.0460.000039%Not Available
Papillary muscle disorder02.04.02.0470.000039%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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